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HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition
Joint Authors
Chen, Yang
Huang, Fei
Deng, liang
Yuan, Xiaowei
Tao, Qiang
Wang, Tielong
Li, Dong
Fan, Youwen
Peng, Quanzhou
Tang, Di
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This paper aims to investigate the function of structural maintenance of chromosome 4 (SMC4) in the progression of hepatocellular carcinoma (HCC) under hypoxic condition.
In this study, we found that suppression of SMC4 could inhibit proliferation and migration of HCC cells through inducing G1 phase arrest and affecting process of epithelial-mesenchymal transition (EMT) under hypoxic condition.
Moreover, we demonstrated that SMC4 was transcriptionally regulated by hypoxia-inducible factor-1 (HIF-1) under hypoxic condition.
As SMC has been shown to be a target gene of miR-219, we observed that miR-219 was downregulated under hypoxic condition and suppression of HIF-1a could lead to the upregulation of miR-219.
We also proved that miR-219 could affect the proliferation and migration of HCC cells under hypoxic condition.
In conclusion, our study demonstrated a novel HIF-1-miR-219-SMC4 regulatory pathway under hypoxic condition in HCC cells.
American Psychological Association (APA)
Chen, Yang& Huang, Fei& Deng, liang& Yuan, Xiaowei& Tao, Qiang& Wang, Tielong…[et al.]. 2019. HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128219
Modern Language Association (MLA)
Chen, Yang…[et al.]. HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1128219
American Medical Association (AMA)
Chen, Yang& Huang, Fei& Deng, liang& Yuan, Xiaowei& Tao, Qiang& Wang, Tielong…[et al.]. HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128219