Boosting Secondary Metabolite Production and Discovery through the Engineering of Novel Microbial Biosensors
Joint Authors
Guazzaroni, María-Eugenia
de Frias, Ulysses Amancio
Pereira, Greicy Kelly Bonifacio
Silva-Rocha, Rafael
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bacteria are a source of a large number of secondary metabolites with several biomedical and biotechnological applications.
In recent years, there has been tremendous progress in the development of novel synthetic biology approaches both to increase the production rate of secondary metabolites of interest in native producers and to mine and reconstruct novel biosynthetic gene clusters in heterologous hosts.
Here, we present the recent advances toward the engineering of novel microbial biosensors to detect the synthesis of secondary metabolites in bacteria and in the development of synthetic promoters and expression systems aiming at the construction of microbial cell factories for the production of these compounds.
We place special focus on the potential of Gram-negative bacteria as a source of biosynthetic gene clusters and hosts for pathway assembly, on the construction and characterization of novel promoters for native hosts, and on the use of computer-aided design of novel pathways and expression systems for secondary metabolite production.
Finally, we discuss some of the potentials and limitations of the approaches that are currently being developed and we highlight new directions that could be addressed in the field.
American Psychological Association (APA)
de Frias, Ulysses Amancio& Pereira, Greicy Kelly Bonifacio& Guazzaroni, María-Eugenia& Silva-Rocha, Rafael. 2018. Boosting Secondary Metabolite Production and Discovery through the Engineering of Novel Microbial Biosensors. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128228
Modern Language Association (MLA)
de Frias, Ulysses Amancio…[et al.]. Boosting Secondary Metabolite Production and Discovery through the Engineering of Novel Microbial Biosensors. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1128228
American Medical Association (AMA)
de Frias, Ulysses Amancio& Pereira, Greicy Kelly Bonifacio& Guazzaroni, María-Eugenia& Silva-Rocha, Rafael. Boosting Secondary Metabolite Production and Discovery through the Engineering of Novel Microbial Biosensors. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128228