Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats
Joint Authors
Park, Young-Bum
Kim, Sungtae
Park, Kyeong-Mee
Kim, Changdae
Park, Wonse
Chung, Moon-Kyu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
In this study, we evaluated changes in bone remodeling in an irradiated rat calvarial defect model according to duration of hyperbaric oxygen therapy.
Materials and Methods.
The 28 rats were divided into four groups.
Radiation of 12 Gy was applied to the skull, and 5-mm critical size defects were formed on both sides of the skull.
Bone grafts were applied to one side of formed defects.
From the day after surgery, HBO was applied for 0, 1, and 3 weeks.
At 6 weeks after bone graft, experimental sites were removed and analyzed for radiography, histology, and histomorphometry.
Results.
Micro-CT analysis showed a significant increase in new bone volume in the HBO-3 group, with or without bone graft.
When bone grafting was performed, BV, BS, and BS/TV all significantly increased.
Histomorphometric analysis showed significant increases in %NBA and %BVN in the HBO-1 and HBO-3 groups, regardless of bone graft.
Conclusion.
Hyperbaric oxygen therapy was effective for bone regeneration with only 1 week of treatment.
American Psychological Association (APA)
Park, Kyeong-Mee& Kim, Changdae& Park, Wonse& Park, Young-Bum& Chung, Moon-Kyu& Kim, Sungtae. 2019. Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128269
Modern Language Association (MLA)
Park, Kyeong-Mee…[et al.]. Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1128269
American Medical Association (AMA)
Park, Kyeong-Mee& Kim, Changdae& Park, Wonse& Park, Young-Bum& Chung, Moon-Kyu& Kim, Sungtae. Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128269