Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoAROCK Signaling in Glioblastoma
Joint Authors
Yu, Guoyong
Wang, Zhaotao
Zeng, Shulian
Liu, Sisi
Zhu, Chunping
Xu, Ruxiang
Liu, Ru-en
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Paeoniflorin (PF), as one of the important valid natural compounds of the total glucosides of peony, has displayed a potential effect in cancer prevention and treatment.
Aggressive migration and invasion, as an important process, can contribute to tumor progression through infiltrating the surround normal tissue.
Actin cytoskeleton rearrangement plays a key role in cells migration and invasion, involving multiple signal pathways.
HGF/c-Met signal, as an important couple of oncoprotein, has been demonstrated to regulate actin cytoskeleton rearrangement.
In our study, we aim to explore whether paeoniflorin can inhibit migration and invasion and actin cytoskeleton rearrangement via regulation of HGF/c-Met/RhoA/ROCK signal.
Various approaches were applied to demonstrate the mechanism of paeoniflorin-mediated anticancer effect, including cell wound healing assay, invasion assay, immunofluorescence staining and transfection, and western blotting.
We observed that paeoniflorin inhibited HGF-induced migration and invasion and actin cytoskeleton rearrangement in glioblastoma cells.
Furthermore, the inhibition of HGF-induced migration and invasion and actin cytoskeleton rearrangement involved c-Met-mediated RhoA/ROCK signaling in glioblastoma.
Thus, our study proved that paeoniflorin could inhibit migration and invasion and actin cytoskeleton rearrangement through inhibition of HGF/c-Met/RhoA/ROCK signaling in glioblastoma, suggesting that paeoniflorin might be a candidate compound to treat glioblastoma.
American Psychological Association (APA)
Yu, Guoyong& Wang, Zhaotao& Zeng, Shulian& Liu, Sisi& Zhu, Chunping& Xu, Ruxiang…[et al.]. 2019. Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoAROCK Signaling in Glioblastoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128278
Modern Language Association (MLA)
Yu, Guoyong…[et al.]. Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoAROCK Signaling in Glioblastoma. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1128278
American Medical Association (AMA)
Yu, Guoyong& Wang, Zhaotao& Zeng, Shulian& Liu, Sisi& Zhu, Chunping& Xu, Ruxiang…[et al.]. Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoAROCK Signaling in Glioblastoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128278