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Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus
Joint Authors
Oleszczuk, Jan
Poniedziałek-Czajkowska, Elżbieta
Mierzyński, Radzisław
Dłuski, Dominik
Nowakowski, Łukasz
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The aim of this study was to determine any changes in adiponectin and omentin levels in GDM patients who delivered at term and preterm and to evaluate whether adipokines can be useful as a clinical biomarker to predict subsequent preterm delivery.
Patients and Methods.
The levels of adiponectin and omentin were measured in four groups: (1) women with GDM who delivered at term (n=63); (2) women with GDM who had the symptoms of threatened preterm labor and delivered at term (n=23); (3) women with GDM and spontaneous preterm birth (before 37 completed weeks of gestation) (n=19); (4) women with physiological pregnancy (n=55).
Results.
In comparison with control group the median adiponectin concentrations were significantly lower in all GDM groups (10737 versus 8879; 7057; 6253 ng/ml, respectively; p<0.01).
The median omentin concentrations were also significantly lower in all GDM groups in comparison with control group (469 versus 432; 357; 308 ng/ml, respectively; p<0.01).
No significant differences in adiponectin and omentin levels between the GDM, preterm labor, and preterm birth groups were observed.
However, there was a trend towards lower adiponectin and omentin levels in preterm birth group.
The strong correlations between adiponectin and omentin levels were observed in all groups (R=0.801, p<0.001; R=0.824, p<0.001; R=0.705, p<0.001; R=0.764, respectively; p<0.001).
In the univariable logistic regression model, significant correlation between omentin concentrations and preterm birth occurrence was found.
Conclusions.
Our findings suggest that omentin-1, rather than adiponectin, could be useful as a predictor of preterm birth in patients with gestational diabetes mellitus.
American Psychological Association (APA)
Mierzyński, Radzisław& Dłuski, Dominik& Nowakowski, Łukasz& Poniedziałek-Czajkowska, Elżbieta& Oleszczuk, Jan. 2018. Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128286
Modern Language Association (MLA)
Mierzyński, Radzisław…[et al.]. Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128286
American Medical Association (AMA)
Mierzyński, Radzisław& Dłuski, Dominik& Nowakowski, Łukasz& Poniedziałek-Czajkowska, Elżbieta& Oleszczuk, Jan. Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128286