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Modulation of Molecular Biomarker Expression in Response to Chemotherapy in Invasive Ductal Carcinoma
Joint Authors
Oloomi, Mana
Bouzari, Saeid
Moazzezy, Neda
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Breast cancer (BC) has varied morphological and biological features and is classified based on molecular and morphological examinations.
Molecular classification of BC is based on biological gene-expression profiling.
In this study, biomarker modulation was assessed during BC treatment in 30 previously untreated patients.
Heterogeneity among patients was pathologically diagnosed and classified into luminal and basal-like immunohistochemical profiles based on estrogen, progesterone, and human epidermal growth factor receptor (ER/PR/HER2) status.
Marker heterogeneity was compared with mRNA biomarker expression in patients with BC before and after therapy.
Reverse transcription-polymerase chain reaction was performed for molecular characterization.
Expression and modulation of biological markers, CK19, hMAM, CEA, MUC, Myc, Ki-67, HER2/neu, ErbB2, and ER, were assessed after treatment, where the expression of the biomarkers CK19, Ki-67, Myc, and CEA was noted to be significantly decreased.
Marker expression modulation was determined according to different stages and pathological characteristics of patients; coexpression of three markers (CK19, Ki-67, and Myc) was specifically modulated after therapy.
In the histopathologically classified basal-like group, two markers (CK19 and Ki-67) were downregulated and could be considered as diagnostic biomarkers.
In conclusion, pathological characteristics and marker variation levels can be evaluated to decide a personalized treatment for patients.
American Psychological Association (APA)
Oloomi, Mana& Moazzezy, Neda& Bouzari, Saeid. 2018. Modulation of Molecular Biomarker Expression in Response to Chemotherapy in Invasive Ductal Carcinoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128289
Modern Language Association (MLA)
Oloomi, Mana…[et al.]. Modulation of Molecular Biomarker Expression in Response to Chemotherapy in Invasive Ductal Carcinoma. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128289
American Medical Association (AMA)
Oloomi, Mana& Moazzezy, Neda& Bouzari, Saeid. Modulation of Molecular Biomarker Expression in Response to Chemotherapy in Invasive Ductal Carcinoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128289