Aging-Induced Biological Changes and Cardiovascular Diseases
Joint Authors
Martins, José Luís Rodrigues
Pedrino, Gustavo Rodrigues
Naves, Lara Marques
Ferreira-Neto, Marcos Luiz
Reis, Angela Adamski da Silva
Cunha, Luiz Carlos da
Saavedra-Rodríguez, Roberto
Rodrigues, Karla Lima
Mourão, Aline Andrade
Silva, Elaine Fernanda da
Williams, Nabofa Enivwenaye Egide
Sousa, Romes Bittencourt
Rebelo, Ana Cristina Silva
Santos, Rodrigo da Silva
Fajemiroye, James Oluwagbamigbe
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aging is characterized by functional decline in homeostatic regulation and vital cellular events.
This process can be linked with the development of cardiovascular diseases (CVDs).
In this review, we discussed aging-induced biological alterations that are associated with CVDs through the following aspects: (i) structural, biochemical, and functional modifications; (ii) autonomic nervous system (ANS) dysregulation; (iii) epigenetic alterations; and (iv) atherosclerosis and stroke development.
Aging-mediated structural and biochemical modifications coupled with gradual loss of ANS regulation, vascular stiffening, and deposition of collagen and calcium often disrupt cardiovascular system homeostasis.
The structural and biochemical adjustments have been consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels.
In addition, cardiomyocyte loss in this process often reduces adaptive capacity and cardiovascular function.
The accumulation of epigenetic changes also plays important roles in the development of CVDs.
In summary, the understanding of the aging-mediated changes remains promising towards effective diagnosis, discovery of new drug targets, and development of new therapies for the treatment of CVDs.
American Psychological Association (APA)
Fajemiroye, James Oluwagbamigbe& Cunha, Luiz Carlos da& Saavedra-Rodríguez, Roberto& Rodrigues, Karla Lima& Naves, Lara Marques& Mourão, Aline Andrade…[et al.]. 2018. Aging-Induced Biological Changes and Cardiovascular Diseases. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128292
Modern Language Association (MLA)
Fajemiroye, James Oluwagbamigbe…[et al.]. Aging-Induced Biological Changes and Cardiovascular Diseases. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1128292
American Medical Association (AMA)
Fajemiroye, James Oluwagbamigbe& Cunha, Luiz Carlos da& Saavedra-Rodríguez, Roberto& Rodrigues, Karla Lima& Naves, Lara Marques& Mourão, Aline Andrade…[et al.]. Aging-Induced Biological Changes and Cardiovascular Diseases. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128292