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Cytotoxicological Investigation of the Essential Oil and the Extracts of Cotula cinerea and Salvia verbenaca from Morocco
Joint Authors
Bakri, Youssef
Taghzouti, Khalid
Guaouguaou, Fatima-Ezzahrae
Bebaha, Mohamed Alien Ahl
Bouyahya, Abdelhakim
Dakka, Nadia
Es-Safi, Nour Eddine
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The objective of this work was to investigate the cytotoxicological effect of the extracts (hexane, ethyl acetate, and n-butanol) of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea.
These plants are widely used in the Moroccan traditional folk medicine.
The cytotoxic effect was explored against two cancer cell lines, Vero and RD, using the colorimetric MTT assay.
The obtained results showed that the cytotoxicity differed according to the used extract with an efficient effect of Cotula cinerea extracts compared to Salvia verbenaca.
A potent cytotoxicity was thus observed for the Cotula cinerea hexane extract which inhibited the growth of RD cell line at the lowest IC50 value (57.21±3.43 µg/mL).
This was followed by the ethyl acetate extract and the essential oil with moderate effects against RD cell line and showed IC50 values of 187.52±6.27 µg/mL and 173.05±4.46 µg/mL, respectively.
On the other hand, different results were obtained and Cotula cinerea essential oil was the most cytotoxic with the lowest IC50 value (72.72±2.18 µg/mL) against Vero cell line.
In the same conditions, higher concentrations were needed in the case of Salvia verbenaca extracts.
The results of this study showed thus that Cotula cinerea essential oil and hexane extract showed significant cytotoxic effects against RD and Vero cell lines, respectively, and could be considered as novel source of antitumor agents.
This study is expected to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further investigations on other types of cancer cell lines.
American Psychological Association (APA)
Guaouguaou, Fatima-Ezzahrae& Bebaha, Mohamed Alien Ahl& Taghzouti, Khalid& Bouyahya, Abdelhakim& Bakri, Youssef& Dakka, Nadia…[et al.]. 2018. Cytotoxicological Investigation of the Essential Oil and the Extracts of Cotula cinerea and Salvia verbenaca from Morocco. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1128298
Modern Language Association (MLA)
Guaouguaou, Fatima-Ezzahrae…[et al.]. Cytotoxicological Investigation of the Essential Oil and the Extracts of Cotula cinerea and Salvia verbenaca from Morocco. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1128298
American Medical Association (AMA)
Guaouguaou, Fatima-Ezzahrae& Bebaha, Mohamed Alien Ahl& Taghzouti, Khalid& Bouyahya, Abdelhakim& Bakri, Youssef& Dakka, Nadia…[et al.]. Cytotoxicological Investigation of the Essential Oil and the Extracts of Cotula cinerea and Salvia verbenaca from Morocco. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1128298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128298