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Azilsartan as “Add-On” Treatment with Methotrexate Improves the Disease Activity of Rheumatoid Arthritis
Joint Authors
Hussain, Saad Abdulrahman
Mahmood, Naza Mohammed Ali
Khan, Hawar Ali Ehsan Kaka
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The present study aimed to evaluate the efficacy and safety of azilsartan (Azil) as “add-on” treatment with methotrexate (MTX) in patients with active rheumatoid arthritis (RA).
Methods.
This single center, randomized, placebo-controlled, double-blind, pilot study included 64 patients with active RA.
Patients received either placebo or Azil in addition to their currently used MTX doses for 90 days.
The primary outcomes were DAS-28, SDAI, HAQ-DI, CDAI, EGA, and swollen and tender joints count.
The secondary outcomes were the changes in the pain visual analogue scale (VAS-100), serum levels of TNF-α, IL-1β, IL-6, and anti-CCP, the lipid profile, and the markers of kidney and liver functions in the two groups at baseline and after 90 days.
Results.
After 90 days, most clinical scores were significantly better in the Azil-treated group than in the placebo group.
All inflammatory biomarkers were significantly improved after treatment with MTX + Azil compared to baseline and placebo group.
No safety concerns were reported during the study period.
Conclusions.
Azilsartan improved the effects of methotrexate on the clinical scores and certain inflammatory biomarkers of patients with active RA.
Trial Registration.
The protocol was registered under the number 507/SA/1024 at the local clinical studies database, College of Medicine, Sulaimani University.
American Psychological Association (APA)
Mahmood, Naza Mohammed Ali& Hussain, Saad Abdulrahman& Khan, Hawar Ali Ehsan Kaka. 2018. Azilsartan as “Add-On” Treatment with Methotrexate Improves the Disease Activity of Rheumatoid Arthritis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128300
Modern Language Association (MLA)
Mahmood, Naza Mohammed Ali…[et al.]. Azilsartan as “Add-On” Treatment with Methotrexate Improves the Disease Activity of Rheumatoid Arthritis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128300
American Medical Association (AMA)
Mahmood, Naza Mohammed Ali& Hussain, Saad Abdulrahman& Khan, Hawar Ali Ehsan Kaka. Azilsartan as “Add-On” Treatment with Methotrexate Improves the Disease Activity of Rheumatoid Arthritis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128300