Inhibiting of Proliferation, Migration, and Invasion in Lung Cancer Induced by Silencing Interferon-Induced Transmembrane Protein 1 (IFITM1)
Joint Authors
Yan, Jun
Jiang, Ying
Lu, Jianfeng
Wu, Jianhui
Zhang, Mingfang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Interferon-induced transmembrane protein 1 (IFITM1), a 17-kDa membrane protein, is generally known as a modulator in many cellular functions.
Recent studies showed overexpression of IFITM1 in cancers and relationship between IFITM1 overexpression and tumor progression.
However, the role of IFITM1 in lung cancer remains unclear.
Here, we presented the overexpression of IFITM1 in lung cancer tissues and cell lines A549 and H460 using quantitative Real-Time RT-PCR.
In vitro assay indicated IFITM1 silencing inhibited lung cancer cell proliferation, migration, and invasion.
Further, in vivo assay showed that IFITM1 silencing markedly suppressed cell growth and metastasis of lung cancer in tumor-bearing BALB/c nude mice.
Mechanistically, we found that IFITM1 silencing significantly alleviated the protein levels of β-catenin, cyclin D1, and c-Mycin lung cancer cells and tumor samples.
Taken together, our study revealed the role of IFITM1 as a tumor promoter during lung cancer development and the possible molecular mechanism.
American Psychological Association (APA)
Yan, Jun& Jiang, Ying& Lu, Jianfeng& Wu, Jianhui& Zhang, Mingfang. 2019. Inhibiting of Proliferation, Migration, and Invasion in Lung Cancer Induced by Silencing Interferon-Induced Transmembrane Protein 1 (IFITM1). BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128306
Modern Language Association (MLA)
Yan, Jun…[et al.]. Inhibiting of Proliferation, Migration, and Invasion in Lung Cancer Induced by Silencing Interferon-Induced Transmembrane Protein 1 (IFITM1). BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1128306
American Medical Association (AMA)
Yan, Jun& Jiang, Ying& Lu, Jianfeng& Wu, Jianhui& Zhang, Mingfang. Inhibiting of Proliferation, Migration, and Invasion in Lung Cancer Induced by Silencing Interferon-Induced Transmembrane Protein 1 (IFITM1). BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128306