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Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis
Joint Authors
Li, Feifei
Jiang, Peipei
Pan, Jinhai
Liu, Chengcheng
Zheng, Liwei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Periodontal bone regeneration relies on coupled and cooperative bone formation and resorption.
Accordingly a novel strategy on concurrent use of platelet-rich fibrin (PRF) (anabolic agent) and 1% alendronate (ALN) (anticatabolic agent) was proposed recently in regenerative periodontal treatment.
It was supposed to enhance bone formation and reduce bone resorption simultaneously.
However, there is a lack of evidence-based studies to answer whether this concurrent application was superior to single application until now.
Besides, concerns on ALN lead to some reservation on this synergistic way.
ALN may impair new bone formation and necrotize jaws.
Thus, in order to compare the clinical efficacy between PRF plus 1%ALN and PRF alone on periodontal bone regeneration, we performed present systematic review and meta-analysis.
Because it is the prerequisite for measuring the combined efficacy of PRF plus 1%ALN, firstly we evaluated the effectiveness of 1%ALN.
Our data indicated that adjunctive 1%ALN was effective in promoting periodontal bone repair.
Further, PRF plus 1%ALN showed a greater capacity for periodontal regeneration than PRF alone with statistical significance.
The findings of this study revealed the promising prospects on synergistic application of bone anabolic agents (PRF) and antiresorption medications (1%ALN) in regenerative periodontal treatment.
American Psychological Association (APA)
Li, Feifei& Jiang, Peipei& Pan, Jinhai& Liu, Chengcheng& Zheng, Liwei. 2019. Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128341
Modern Language Association (MLA)
Li, Feifei…[et al.]. Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1128341
American Medical Association (AMA)
Li, Feifei& Jiang, Peipei& Pan, Jinhai& Liu, Chengcheng& Zheng, Liwei. Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128341