Biological Aspect of Pathophysiology for Frozen Shoulder
Joint Authors
Song, K. S.
Cho, Chul-Hyun
Kim, Beom-Soo
Kim, Du Hwan
Lho, Yun-Mee
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It is fairly well understood that frozen shoulder involves several stages, which reflect the series of process from capsular inflammation and fibrosis to spontaneous resolution of this fibrosis.
However, the underlying pathophysiologic process remains poorly determined.
For this reason, management of frozen shoulder remains controversial.
Determining the pathophysiological processes of frozen shoulder is a pivotal milestone in the development of novel treatment for patients with frozen shoulder.
This article reviews what is known to date about the biological pathophysiology of frozen shoulder.
Although articles for the pathophysiology of frozen shoulder provide inconsistent and inconclusive results, they have suggested both inflammation and fibrosis mediated by cytokines, growth factors, matrix metalloproteinases, and immune cells.
Proinflammatory cytokines and growth factors released from immune cells control the action of fibroblast and matrix remodeling is regulated by the matrix metalloproteinases and their inhibitors.
To improve our understanding of the disease continuum, better characterizing the biology of these processes at clearly defined stages will be needed.
Further basic studies that use standardized protocols are required to more narrowly identify the role of cytokines, growth factors, matrix metalloproteinases, and immune cells.
The results of these studies will provide needed clarity into the control mechanism of the pathogenesis of frozen shoulder and help identify new therapeutic targets for its treatment.
American Psychological Association (APA)
Cho, Chul-Hyun& Song, K. S.& Kim, Beom-Soo& Kim, Du Hwan& Lho, Yun-Mee. 2018. Biological Aspect of Pathophysiology for Frozen Shoulder. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128363
Modern Language Association (MLA)
Cho, Chul-Hyun…[et al.]. Biological Aspect of Pathophysiology for Frozen Shoulder. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128363
American Medical Association (AMA)
Cho, Chul-Hyun& Song, K. S.& Kim, Beom-Soo& Kim, Du Hwan& Lho, Yun-Mee. Biological Aspect of Pathophysiology for Frozen Shoulder. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128363