Subchronic Study of a White Kidney Bean (Phaseolus vulgaris) Extract with α-Amylase Inhibitory Activity
Joint Authors
Qin, Guangqiu
Wang, Fang
Liang, Huili
Tang, Song
Shekh, Kamran
Wang, Yanwu
Li, Bin
Dong, Baiqing
Wen, Pingjing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Common bean extract as a dietary supplement has received increased attention globally owing to its α-amylase inhibitory activity.
The objective of this study was to evaluate the toxicity of a white kidney bean (Phaseolus vulgaris) extract by a repeated-dose 90-day subchronic oral toxicity study in Sprague-Dawley rats.
In the subchronic toxicity study, 80 rats were orally administrated with white kidney bean extract at doses of 4, 2, and 1 g/kg body weight daily for 90 days.
The results showed that the white kidney bean extract at doses up to 4 g/kg/day did not induce significant changes in body weight, organ weight, food consumption, hematology, serum biochemistry, and histopathology in rats, as compared to the control.
The no-observed-adverse-effect level (NOAEL) of white kidney bean extract was determined to be >4 g/kg/day for both male and female rats, under the experimental conditions of this study.
American Psychological Association (APA)
Qin, Guangqiu& Wang, Fang& Liang, Huili& Tang, Song& Shekh, Kamran& Wang, Yanwu…[et al.]. 2019. Subchronic Study of a White Kidney Bean (Phaseolus vulgaris) Extract with α-Amylase Inhibitory Activity. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128419
Modern Language Association (MLA)
Qin, Guangqiu…[et al.]. Subchronic Study of a White Kidney Bean (Phaseolus vulgaris) Extract with α-Amylase Inhibitory Activity. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1128419
American Medical Association (AMA)
Qin, Guangqiu& Wang, Fang& Liang, Huili& Tang, Song& Shekh, Kamran& Wang, Yanwu…[et al.]. Subchronic Study of a White Kidney Bean (Phaseolus vulgaris) Extract with α-Amylase Inhibitory Activity. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128419