Screening Potential Probiotic Characteristics of Lactobacillus brevis Strains In Vitro and Intervention Effect on Type I Diabetes In Vivo
Joint Authors
Sami, Rokayya
Abdelazez, Amro
Jia, Fang-Fang
Meng, Xiang-Chen
Abdelmotaal, Heba
Evivie, Smith Etareri
Melak, Sherif
Khoso, Mir Hassan
Zhu, Zong-Tao
Zhang, Lu-Ji
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Diabetes has become the third most serious threat to human health, after cancer and cardiovascular disease.
Notably, Lactobacillus brevis is the most common species of LAB that produces γ-aminobutyric acid (GABA).
The aim of this study is to clarify the effect of time, strain types, antibiotic concentrations, different levels of pH, and intestinal juices in aerobic or anaerobic conditions and the effect of interactions between these factors on the potential properties of KLDS 1.0727 and KLDS 1.0373, furthermore, antagonistic activity against foodborne pathogens.
Moreover, another aim is to study the capability of KLDS 1.0727 and KLDS 1.0373 strains as gad gene carriers to express GABA that reduce the risk of type 1 diabetes in C57BL/6 mice as diabetic models.
The obtained results exhibited the surprising tolerance of Lactobacillus brevis strains in vitro digestion models mimicking the conditions of the gastrointestinal tract, further, large antagonistic activity against foodborne pathogeneses.
In vivo results displayed the significant effect on glucose level reduction, blood plasma, and histological assays of mice organs.
As recommended, the use of Lactobacillus brevis strains should be widely shared in the market as a natural source of GABA in pharmaceutical and food applications.
American Psychological Association (APA)
Abdelazez, Amro& Abdelmotaal, Heba& Evivie, Smith Etareri& Melak, Sherif& Jia, Fang-Fang& Khoso, Mir Hassan…[et al.]. 2018. Screening Potential Probiotic Characteristics of Lactobacillus brevis Strains In Vitro and Intervention Effect on Type I Diabetes In Vivo. BioMed Research International،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1128421
Modern Language Association (MLA)
Abdelazez, Amro…[et al.]. Screening Potential Probiotic Characteristics of Lactobacillus brevis Strains In Vitro and Intervention Effect on Type I Diabetes In Vivo. BioMed Research International No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1128421
American Medical Association (AMA)
Abdelazez, Amro& Abdelmotaal, Heba& Evivie, Smith Etareri& Melak, Sherif& Jia, Fang-Fang& Khoso, Mir Hassan…[et al.]. Screening Potential Probiotic Characteristics of Lactobacillus brevis Strains In Vitro and Intervention Effect on Type I Diabetes In Vivo. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1128421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128421