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Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis
Joint Authors
Hu, Gang
Liu, Qin
Ma, Jian-ying
Liu, Cheng-yuan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Pretreatment platelet-to-lymphocyte ratio (PLR) has been considered a prognostic factor in various cancers.
However, the application of PLR in the assessment of patients with cholangiocarcinoma remains controversial.
This study aimed to evaluate the prognostic value of pretreatment PLR in cholangiocarcinoma.
Methods.
A systematic search was performed in MEDLINE, EMBASE, and Cochrane Library to identify studies assessing the prognostic significance of the pretreatment PLR in cholangiocarcinoma.
Three databases were searched from inception to August 5, 2018.
The primary outcome was overall survival (OS), and the secondary outcomes were recurrence-free survival (RFS) and progression-free survival (PFS).
Pooled hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models.
Results.
A total of 9 studies including 2395 patients were finally enrolled in the meta-analysis based on the inclusion and exclusion criteria.
All of the included studies were retrospective observational cohorts.
Elevated PLR predicted poor OS (HR: 1.38, 95% CI: 1.19-1.62, P < 0.001) and RFS or PFS (HR = 1.55; 95% CI = 1.27-1.88; P < 0.001).
Moreover, elevated PLR was highly associated with male sex (male versus female OR = 0.59, 95% CI: 0.44-0.80, P < 0.001) and R1 resection margin (OR = 2.09, 95% CI: 1.24-3.54, P = 0.006).
Conclusion.
The present meta-analysis demonstrated that pretreatment PLR might serve as a useful prognostic biomarker in cholangiocarcinoma.
American Psychological Association (APA)
Hu, Gang& Liu, Qin& Ma, Jian-ying& Liu, Cheng-yuan. 2018. Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128437
Modern Language Association (MLA)
Hu, Gang…[et al.]. Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128437
American Medical Association (AMA)
Hu, Gang& Liu, Qin& Ma, Jian-ying& Liu, Cheng-yuan. Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128437