Antidepressant-Like and Neuroprotective Effects of Ethanol Extract from the Root Bark of Hibiscus syriacus L.
Joint Authors
Im, A-Rang
Kim, Young-Hwa
Oh, Seung-Eun
Kim, Yu Ri
Park, Bo-Kyung
Paek, Seung Ho
Choi, Goya
Lee, Kang Hee
Whang, Wan Kyunn
Lee, Mi-Young
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hibiscus syriacus L.
(Malvaceae) is an important ornamental shrub in horticulture and has been widely used as a medical material in Asia.
The aim of this study was to assess the antidepressant and neuroprotective effects of a root bark extract of H.
syriacus (HSR) and to investigate the underlying molecular mechanisms.
Using an animal model of restraint stress, we investigated the effects of HSR on depressive-like behaviors and on the expression levels of serotonin, corticosterone, and neurotrophic factors in the brain.
The mice were exposed to restraint stress for 2 h per day over a period of 3 weeks and orally treated with HSR (100, 200, or 400 mg/kg/day).
We also examined the neuroprotective effect of HSR using corticosterone-treated human neuroblastoma SK-N-SH cells.
The cells were incubated with the extract for 24 h, followed by corticosterone stimulation for 1 h, and then cell viability assay, cellular ATP assay, mitochondrial membrane potential (MMP) assay, cellular reactive oxygen species (ROS) assay, and western blotting were used to investigate the neuroprotective effects of HSR.
Administration of HSR not only reduced the immobility times of the restraint-stressed mice in the forced swimming and tail suspension tests, but also significantly increased sucrose preference in the sucrose preference test.
In addition, HSR significantly reduced the plasma levels of corticosterone and increased the brain levels of serotonin.
The extract also increased the phosphorylation level of cyclic AMP response element-binding (CREB) protein and the expression level of brain-derived neurotrophic factor (BDNF).
The in vitro assays showed that HSR pretreatment increased cell viability and ATP levels, recovered MMP, decreased ROS levels, and increased the expression of CREB and BDNF in corticosterone-induced neurotoxicity.
Taken together, our data suggest that HSR may have the potential to control neuronal cell damage and depressive behaviors caused by chronic stress.
American Psychological Association (APA)
Kim, Young-Hwa& Im, A-Rang& Park, Bo-Kyung& Paek, Seung Ho& Choi, Goya& Kim, Yu Ri…[et al.]. 2018. Antidepressant-Like and Neuroprotective Effects of Ethanol Extract from the Root Bark of Hibiscus syriacus L.. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128451
Modern Language Association (MLA)
Kim, Young-Hwa…[et al.]. Antidepressant-Like and Neuroprotective Effects of Ethanol Extract from the Root Bark of Hibiscus syriacus L.. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1128451
American Medical Association (AMA)
Kim, Young-Hwa& Im, A-Rang& Park, Bo-Kyung& Paek, Seung Ho& Choi, Goya& Kim, Yu Ri…[et al.]. Antidepressant-Like and Neuroprotective Effects of Ethanol Extract from the Root Bark of Hibiscus syriacus L.. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128451