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Proinflammatory Role of Angiotensin II in the Aorta of Normotensive Mice
Joint Authors
Lima, Rariane Silva de
Silva, Juliane Cristina de Souza
Lima, Cintia Taniguti
Silva, Maikon Barbosa da
Baladi, Marina Gazzano
Souza, Leandro E.
Irigoyen, Maria Claúdia C.
Lacchini, Silvia
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Angiotensin II plays important functions in cardiovascular system mediating actions leading to inflammatory responses such as activation of VSMC in order to produce ROS, inflammatory cytokines, chemokines, and adhesion molecules.
Changes in angiotensin II production could stimulate the recruitment and activation of myeloid cells initiating local inflammatory response without effect on BP.
We aimed to verify if angiotensin II induces an inflammatory response in the aorta and if it correlates with variations in BP.
C57Bl/6 mice treated with saline solution (0.9%, control group) or angiotensin II (30ng/kg, Ang II group) were used.
BP and HR levels were measured.
Immunohistochemistry for IL1-β, TGF-β, iNOS, CD45, and α-actin was performed in the aorta.
BP and HR do not change.
A biphasic response was observed both for IL1-β and TGF-β expression and also for the presence of CD45 positive cells, with an acute increase (between 30 and 60 minutes) and a second increase, between 24 and 48 hours.
Positive staining for iNOS increased in the earlier period (30 minutes) in perivascular adipose tissue and in a longer period (48 hours) in tunica adventitia.
Immunoblotting to α-actin showed no alterations, suggesting that the applied dose of angiotensin II does not alter the aortic VSMCs phenotype.
The results suggest that angiotensin II, even at doses that do not alter BP, induces the expression of inflammatory markers and migration of inflammatory cells into the aorta of normotensive mice.
Thus, angiotensin II may increase the propensity to develop a cardiovascular injury, even in normotensive individuals.
American Psychological Association (APA)
Lima, Rariane Silva de& Silva, Juliane Cristina de Souza& Lima, Cintia Taniguti& Souza, Leandro E.& Silva, Maikon Barbosa da& Baladi, Marina Gazzano…[et al.]. 2019. Proinflammatory Role of Angiotensin II in the Aorta of Normotensive Mice. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128472
Modern Language Association (MLA)
Lima, Rariane Silva de…[et al.]. Proinflammatory Role of Angiotensin II in the Aorta of Normotensive Mice. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1128472
American Medical Association (AMA)
Lima, Rariane Silva de& Silva, Juliane Cristina de Souza& Lima, Cintia Taniguti& Souza, Leandro E.& Silva, Maikon Barbosa da& Baladi, Marina Gazzano…[et al.]. Proinflammatory Role of Angiotensin II in the Aorta of Normotensive Mice. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128472