A Proposed Approach for Joint Modeling of the Longitudinal and Time-To-Event Data in Heterogeneous Populations: An Application to HIVAIDS’s Disease
Joint Authors
Zare, Najaf
Ayatollahi, Seyyed Mohammad Taghi
Roustaei, Narges
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In recent years, the joint models have been widely used for modeling the longitudinal and time-to-event data simultaneously.
In this study, we proposed an approach (PA) to study the longitudinal and survival outcomes simultaneously in heterogeneous populations.
PA relaxes the assumption of conditional independence (CI).
We also compared PA with joint latent class model (JLCM) and separate approach (SA) for various sample sizes (150, 300, and 600) and different association parameters (0, 0.2, and 0.5).
The average bias of parameters estimation (AB-PE), average SE of parameters estimation (ASE-PE), and coverage probability of the 95% confidence interval (CP) among the three approaches were compared.
In most cases, when the sample sizes increased, AB-PE and ASE-PE decreased for the three approaches, and CP got closer to the nominal level of 0.95.
When there was a considerable association, PA in comparison with SA and JLCM performed better in the sense that PA had the smallest AB-PE and ASE-PE for the longitudinal submodel among the three approaches for the small and moderate sample sizes.
Moreover, JLCM was desirable for the none-association and the large sample size.
Finally, the evaluated approaches were applied on a real HIV/AIDS dataset for validation, and the results were compared.
American Psychological Association (APA)
Roustaei, Narges& Ayatollahi, Seyyed Mohammad Taghi& Zare, Najaf. 2018. A Proposed Approach for Joint Modeling of the Longitudinal and Time-To-Event Data in Heterogeneous Populations: An Application to HIVAIDS’s Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128485
Modern Language Association (MLA)
Roustaei, Narges…[et al.]. A Proposed Approach for Joint Modeling of the Longitudinal and Time-To-Event Data in Heterogeneous Populations: An Application to HIVAIDS’s Disease. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1128485
American Medical Association (AMA)
Roustaei, Narges& Ayatollahi, Seyyed Mohammad Taghi& Zare, Najaf. A Proposed Approach for Joint Modeling of the Longitudinal and Time-To-Event Data in Heterogeneous Populations: An Application to HIVAIDS’s Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128485