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Mechanisms of Intravascular Linear Ablation Induced Restenosis in Rabbit Abdominal Aorta
Joint Authors
Tse, Gary
Li, Guangping
Chen, Qiang
Wang, Manman
Shao, Shuai
Liu, Hongze
Xia, Xiaodong
Yuan, Meng
Zhang, Yue
Liang, Xue
Liu, Tong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objectives.
Percutaneous coronary intervention (PCI) is the mainstay treatment for coronary artery disease but complications such as in-stent restenosis and thrombosis remain problematic.
Radiofrequency balloon angioplasty (RBA) can improve lumen dimension, fusing intimal tears, and artery dissection but is associated with higher restenosis rate.
Methods.
After establishing an atherosclerosis model based on endothelial abrasion and high cholesterol diet, forty-five rabbits were randomly divided into three groups: RBA (n=20), percutaneous transluminal angioplasty (PTA) (n=20), and control groups (n=5).
The RBA and PTA groups were subdivided according to harvested time posttreatment, respectively (1 hour, 7 days, 14 days, and 28 days).
Aorta segments were then isolated for hematoxylin and eosin staining, Masson trichrome staining, immunohistochemistry, and Western blot for TLR-4, NF-κB, MCP-1, and VCAM-1expression.
Results.
At 28 days, intimal area was significantly lower in the RBA group compared to the PTA and control groups, whilst luminal and medial area were comparable in the RBA and PTA group but higher and lower than the control group, respectively.
Expression of TLR-4, NF-κB, MCP-1, and VCAM-1 showed no significant difference between RBA and PTA groups.
Conclusions.
RBA can depress the intimal hyperplasia and promote dilatation of the artery to greater extents than PTA at 28 days.
However, this did not involve TLR-4 signaling pathway, which likely plays a negligible role in mediating restenosis.
Reduction of intimal hyperplasia may be due to injury of ablation to the tunica media and inhibition of VSMC proliferation and migration.
American Psychological Association (APA)
Chen, Qiang& Wang, Manman& Shao, Shuai& Liu, Hongze& Xia, Xiaodong& Tse, Gary…[et al.]. 2018. Mechanisms of Intravascular Linear Ablation Induced Restenosis in Rabbit Abdominal Aorta. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128511
Modern Language Association (MLA)
Chen, Qiang…[et al.]. Mechanisms of Intravascular Linear Ablation Induced Restenosis in Rabbit Abdominal Aorta. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1128511
American Medical Association (AMA)
Chen, Qiang& Wang, Manman& Shao, Shuai& Liu, Hongze& Xia, Xiaodong& Tse, Gary…[et al.]. Mechanisms of Intravascular Linear Ablation Induced Restenosis in Rabbit Abdominal Aorta. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128511