The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys
Joint Authors
Ostróżka-Cieślik, Aneta
Dolińska, Barbara
Ryszka, Florian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Biolasol is a newly developed solution for storing the liver, pancreas, kidneys, and heart by simple hypothermia.
It exhibits high efficacy in maintaining structural and functional integrity of the graft prior to its transplantation.
The solution was modified by the addition of ascorbic acid (0.088g/l) and ascorbic acid with prolactin (1 μg/l PRL + 0.088g/l vitamin C).
The effectiveness of the obtained solutions in the protection of nephrons of isolated porcine kidneys was assessed based on the analysis of the activity of ALT (alanine aminotransferase), AST (aspartate aminotransferase), and LDH (lactate dehydrogenase) as well as lactate concentration determined in perfundates collected after 2 h (0′ and 30′ preservation) and 48 h (0′ and 30′ preservation) of graft storage.
It has been found that the synergistic action of Biolasol components determines the integrity and stability of cell membranes, which in turn affects the proper functioning of the organ after transplantation.
The addition of ascorbic acid and prolactin to Biolasol affects the maintenance of the normal cytoskeleton of the stored graft.
American Psychological Association (APA)
Ostróżka-Cieślik, Aneta& Dolińska, Barbara& Ryszka, Florian. 2018. The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128521
Modern Language Association (MLA)
Ostróżka-Cieślik, Aneta…[et al.]. The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128521
American Medical Association (AMA)
Ostróżka-Cieślik, Aneta& Dolińska, Barbara& Ryszka, Florian. The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128521