APLP2 Modulates JNK-Dependent Cell Migration in Drosophila
Joint Authors
Xue, Lei
Wang, Xingjun
Guo, Xiaowei
Ma, Yeqing
Wu, Chenxi
Li, Wenzhe
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Amyloid precursor-like protein 2 (APLP2) belongs to the APP family and is widely expressed in human cells.
Though previous studies have suggested a role of APLP2 in cancer progression, the exact role of APLP2 in cell migration remains elusive.
Here in this report, we show that ectopic expression of APLP2 in Drosophila induces cell migration which is mediated by JNK signaling, as loss of JNK suppresses while gain of JNK enhances such phenotype.
APLP2 is able to activate JNK signaling by phosphorylation of JNK, which triggers the expression of matrix metalloproteinase MMP1 required for basement membranes degradation to promote cell migration.
The data presented here unraveled an in vivo role of APLP2 in JNK-mediated cell migration.
American Psychological Association (APA)
Wang, Xingjun& Guo, Xiaowei& Ma, Yeqing& Wu, Chenxi& Li, Wenzhe& Xue, Lei. 2018. APLP2 Modulates JNK-Dependent Cell Migration in Drosophila. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128530
Modern Language Association (MLA)
Wang, Xingjun…[et al.]. APLP2 Modulates JNK-Dependent Cell Migration in Drosophila. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128530
American Medical Association (AMA)
Wang, Xingjun& Guo, Xiaowei& Ma, Yeqing& Wu, Chenxi& Li, Wenzhe& Xue, Lei. APLP2 Modulates JNK-Dependent Cell Migration in Drosophila. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128530