The MicroRNA Family Both in Normal Development and in Different Diseases: The miR-17-92 Cluster
Joint Authors
Zhang, Junping
Bai, Xiaodan
Hua, Shengyu
Xu, Shixin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
An increasing number of research studies over recent years have focused on the function of microRNA (miRNA) molecules which have unique characteristics in terms of structure and function.
They represent a class of endogenous noncoding single-strand small molecules.
An abundance of miRNA clusters has been found in the genomes of various organisms often located in a polycistron.
The miR-17-92 family is among the most famous miRNAs and has been identified as an oncogene.
The functions of this cluster, together with the seven individual molecules that it comprises, are most related to cancers, so it would not be surprising that they are considered to have involvement in the development of tumors.
The miR-17-92 cluster is therefore expected not only to be a tumor marker, but also to perform an important role in the early diagnosis of those diseases and possibly also be a target for tumor biotherapy.
The miR-17-92 cluster affects the development of disease by regulating many related cellular processes and multiple target genes.
Interestingly, it also has important roles that cannot be ignored in disease of the nervous system and circulation and modulates the growth and development of bone.
Therefore, it provides new opportunities for disease prevention, clinical diagnosis, prognosis, and targeted therapy.
Here we review the role of the miR-17-92 cluster that has received little attention in relation to neurological diseases, cardiac diseases, and the development of bone and tumors.
American Psychological Association (APA)
Bai, Xiaodan& Hua, Shengyu& Zhang, Junping& Xu, Shixin. 2019. The MicroRNA Family Both in Normal Development and in Different Diseases: The miR-17-92 Cluster. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128542
Modern Language Association (MLA)
Bai, Xiaodan…[et al.]. The MicroRNA Family Both in Normal Development and in Different Diseases: The miR-17-92 Cluster. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1128542
American Medical Association (AMA)
Bai, Xiaodan& Hua, Shengyu& Zhang, Junping& Xu, Shixin. The MicroRNA Family Both in Normal Development and in Different Diseases: The miR-17-92 Cluster. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128542