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Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?
Author
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The Janus Kinases (JAKs) are a family of intracellular tyrosine kinases that provide transmission signals from cytokine, interferons, and many hormones receptors to the nucleus resulting in synthesis of many biologically active compounds and changing cell metabolism and function.
That was theoretical background to synthetize the JAK inhibitors (Jakinibs).
In recent years a substantial battery of evidence has been collected indicating the potential role of Jakinibs to interact with the specific elements of the immune system, therefore changing the inflammatory response.
JAK kinase blockade offers a unique opportunity to block most of the key cytokines enabling the deep interaction into immune system functioning.
Following discovery first Jakinibs were intensively studied in various forms of autoimmune diseases, including rheumatoid arthritis, and finally two Jakinibs tofacitinib and Baricitinib have been approved for the treatment of rheumatoid arthritis.
Some clinical data indicated that under special circumstances Jakinibs may be even superior to biologics in the treatment of RA; however this suggestion should be verified in large clinical and observational studies.
American Psychological Association (APA)
Kotyla, Przemyslaw J.. 2018. Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128564
Modern Language Association (MLA)
Kotyla, Przemyslaw J.. Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128564
American Medical Association (AMA)
Kotyla, Przemyslaw J.. Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128564