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Risk of Urinary Tract Carcinoma among Subjects with Bladder Pain SyndromeInterstitial Cystitis: A Nationwide Population-Based Study
Joint Authors
Wu, Ming-Ping
Ho, Chung-Han
Weng, Shih-Feng
Luo, Hao Lun
Chancellor, Michael B.
Chuang, Yao Chi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To investigate the subsequent risks of urinary tract cancers among individuals with bladder pain syndrome/interstitial cystitis (BPS/IC), and gender differences, as well as the effect of associated comorbidity using a population-based administrative database in Taiwan.
Patients and Methods.
BPS/IC subjects (10192) and their age- and sex-matched non-BPS/IC control subjects (30576), who had no previous upper urinary tract cancer (UUC), bladder cancer (BC), and prostate cancer (PC), subsequently developed these disorders from the recruited date between 2002 and 2008 and the end of follow-up 2011.
A Cox proportional hazards regression model was constructed to estimate the risk of subsequent UUC, BC, and PC following a diagnosis of IC/BPS.
The effect of associated comorbidities was measured by Charlson Comorbidity Index (CCI).
The risk of outcomes was assessed with Kaplan-Meier curves.
Results.
In the BPS/IC subjects, 37 (0.36%) received a diagnosis of BC, and 22 (0.22%) received a diagnosis of UUC; both were significantly higher than the control group, 19 (0.06%) for BC and 30 (0.10%) for UUC.
Cox proportional analysis revealed that the adjusted HR for BC and UUC during the follow-up period for patients with IC/BPS was 5.44 (95% CI: 3.10-9.54) and 1.97 (95% CI: 1.13-3.45) than that of comparison subjects.
The HRs went up to 5.66 (95% CI: 3.21-9.99) and 2.01 (95% CI: 1.14-3.55) after adjusted by Comorbidity Index (CCI).
The male BPS/IC patients have a higher adjusted HR for BC; however, female patients have a higher adjusted HR for both BC and UUC.
The adjusted HR for PC has no difference between BPS/IC and control group.
Conclusion.
Patients with BPS/IC are at risk of developing BC in both males and females, and UUC in females.
This result reminds physicians to evaluate the potential risk of subsequent development of BC and UUC among individuals with BPS/IC.
American Psychological Association (APA)
Wu, Ming-Ping& Luo, Hao Lun& Weng, Shih-Feng& Ho, Chung-Han& Chancellor, Michael B.& Chuang, Yao Chi. 2018. Risk of Urinary Tract Carcinoma among Subjects with Bladder Pain SyndromeInterstitial Cystitis: A Nationwide Population-Based Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128566
Modern Language Association (MLA)
Wu, Ming-Ping…[et al.]. Risk of Urinary Tract Carcinoma among Subjects with Bladder Pain SyndromeInterstitial Cystitis: A Nationwide Population-Based Study. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128566
American Medical Association (AMA)
Wu, Ming-Ping& Luo, Hao Lun& Weng, Shih-Feng& Ho, Chung-Han& Chancellor, Michael B.& Chuang, Yao Chi. Risk of Urinary Tract Carcinoma among Subjects with Bladder Pain SyndromeInterstitial Cystitis: A Nationwide Population-Based Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128566