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The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels
Joint Authors
Ren, Guo
Hu, Jing
Xiao, Xue-Fei
Peng, Yue
Zhao, Shang-Ping
Xiao, Xian-Zhong
Yang, Ming-Shi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sepsis is a severe and progressive disease characterized by systemic inflammatory response syndrome (SIRS).
CD40 serves as a vital link between immune response and inflammation.
This study was designed to investigate the potential association between a functional single-nucleotide polymorphism (SNP) of CD40 (rs1883832) and susceptibility to sepsis.
We first performed a case-control study to explore the relationship between the CD40 rs1883832 polymorphism and sepsis.
CD40 mRNA expression and protein expression were determined by real-time PCR and western blotting, respectively, in peripheral blood mononuclear cells (PBMCs) from sepsis patients and healthy controls.
The plasma sCD40L levels in the two groups were measured by ELISA.
The results showed that the frequencies of the TT genotype and the CD40 rs1883832 T allele were significantly higher in sepsis patients than in healthy controls.
Plasma sCD40L levels were also significantly increased in sepsis patients.
In addition, TT genotype carriers among sepsis patients displayed the highest CD40 expression at both the mRNA and protein levels, accompanied by the highest plasma sCD40L concentrations.
In conclusion, the CD40 rs1883832 T allele acts as a risk factor for increased susceptibility to sepsis and may be involved in the process of sepsis through regulation of CD40 expression and plasma sCD40L levels.
American Psychological Association (APA)
Ren, Guo& Hu, Jing& Xiao, Xue-Fei& Peng, Yue& Zhao, Shang-Ping& Xiao, Xian-Zhong…[et al.]. 2018. The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128568
Modern Language Association (MLA)
Ren, Guo…[et al.]. The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128568
American Medical Association (AMA)
Ren, Guo& Hu, Jing& Xiao, Xue-Fei& Peng, Yue& Zhao, Shang-Ping& Xiao, Xian-Zhong…[et al.]. The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128568