Orostachys japonicus A. Berger Extracts Induce Immunity-Enhancing Effects on Cyclophosphamide-Treated Immunosuppressed Rats
Joint Authors
Kim, Min Jung
Yang, Hye Jeong
Lee, Hak Yong
Park, Young Mi
Kim, Jeong
Oh, Hong Geun
Kang, Hee Joo
Kim, Ri Rang
Kim, Sang Hee
Oh, Jisun
Kim, Kang Sung
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this study, we evaluated the immunity-enhancing effects of Orostachys japonicus A.
Berger (OJ).
To examine the immune protective effect in vitro, primary mouse splenocytes were treated with water or ethanol extracts of OJ in the absence or presence of cyclophosphamide (CY), which is a cytotoxic, immunosuppressive agent.
The extracts increased the propagation of splenocytes and inhibited CY-induced cytotoxicity.
Further, to examine the immunostimulatory effects in vivo, adult Wistar rats were orally administered OJ extracts with or without CY treatment.
With the administration of OJ extracts, CY-treated immunosuppressed rats showed improved physical endurance, as assessed by the forced swim test.
In addition, extract administration increased not only the number of immunity-related cells but also the levels of plasma cytokines.
OJ extracts also recovered splenic histology in CY-treated rats.
These findings suggest that an OJ regimen can enhance immunity by increasing immune cell propagation and specific plasma cytokine levels.
American Psychological Association (APA)
Lee, Hak Yong& Park, Young Mi& Kim, Jeong& Oh, Hong Geun& Kim, Kang Sung& Kang, Hee Joo…[et al.]. 2019. Orostachys japonicus A. Berger Extracts Induce Immunity-Enhancing Effects on Cyclophosphamide-Treated Immunosuppressed Rats. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128571
Modern Language Association (MLA)
Lee, Hak Yong…[et al.]. Orostachys japonicus A. Berger Extracts Induce Immunity-Enhancing Effects on Cyclophosphamide-Treated Immunosuppressed Rats. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1128571
American Medical Association (AMA)
Lee, Hak Yong& Park, Young Mi& Kim, Jeong& Oh, Hong Geun& Kim, Kang Sung& Kang, Hee Joo…[et al.]. Orostachys japonicus A. Berger Extracts Induce Immunity-Enhancing Effects on Cyclophosphamide-Treated Immunosuppressed Rats. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128571