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Desflurane Attenuates Ventilator-Induced Lung Injury in Rats with Acute Respiratory Distress Syndrome
Joint Authors
Lin, Xue
Ju, Ying-nan
Gao, Wei
Li, Dong-mei
Guo, Chang-chun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ventilator-induced lung injury aggravates the existing lung injury.
This study investigated the effect of desflurane on VILI in a rat model of acute respiratory distress syndrome.
Forty-eight rats were randomized into a sham (S) group, control (C) group, lipopolysaccharide/ventilation (LV) group, lipopolysaccharide/ventilation/desflurane (LVD) group, or lipopolysaccharide/low ventilation with and without desflurane (LLV and LLVD) groups.
Rats in the S group received anesthesia only.
Rats in the LV and LVD groups received lipopolysaccharide and were ventilated with a high tidal volume.
Rats in LLV and LLVD groups were treated as the LV and LVD groups and ventilated with a low tidal volume.
PaO2/FiO2, lung wet-to-dry weight ratios, concentrations of inflammatory factors in serum and BALF, histopathologic analysis of lung tissue, and levels of nuclear factor- (NF-) κB protein in lung tissue were investigated.
PaO2/FiO2 was significantly increased by desflurane.
Total cell count, macrophages, and neutrophils in BALF and proinflammatory factors in BALF and serum were significantly decreased by desflurane, while IL-10 was increased.
The histopathological changes and levels of NF-κB protein in lung tissue were decreased by desflurane.
The results indicated that desflurane ameliorated VILI in a rat model of acute respiratory distress syndrome.
American Psychological Association (APA)
Lin, Xue& Ju, Ying-nan& Gao, Wei& Li, Dong-mei& Guo, Chang-chun. 2018. Desflurane Attenuates Ventilator-Induced Lung Injury in Rats with Acute Respiratory Distress Syndrome. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128573
Modern Language Association (MLA)
Lin, Xue…[et al.]. Desflurane Attenuates Ventilator-Induced Lung Injury in Rats with Acute Respiratory Distress Syndrome. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128573
American Medical Association (AMA)
Lin, Xue& Ju, Ying-nan& Gao, Wei& Li, Dong-mei& Guo, Chang-chun. Desflurane Attenuates Ventilator-Induced Lung Injury in Rats with Acute Respiratory Distress Syndrome. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128573