Desflurane Attenuates Ventilator-Induced Lung Injury in Rats with Acute Respiratory Distress Syndrome

Abstract EN

Ventilator-induced lung injury aggravates the existing lung injury.

This study investigated the effect of desflurane on VILI in a rat model of acute respiratory distress syndrome.

Forty-eight rats were randomized into a sham (S) group, control (C) group, lipopolysaccharide/ventilation (LV) group, lipopolysaccharide/ventilation/desflurane (LVD) group, or lipopolysaccharide/low ventilation with and without desflurane (LLV and LLVD) groups.

Rats in the S group received anesthesia only.

Rats in the LV and LVD groups received lipopolysaccharide and were ventilated with a high tidal volume.

Rats in LLV and LLVD groups were treated as the LV and LVD groups and ventilated with a low tidal volume.

PaO2/FiO2, lung wet-to-dry weight ratios, concentrations of inflammatory factors in serum and BALF, histopathologic analysis of lung tissue, and levels of nuclear factor- (NF-) κB protein in lung tissue were investigated.

PaO2/FiO2 was significantly increased by desflurane.

Total cell count, macrophages, and neutrophils in BALF and proinflammatory factors in BALF and serum were significantly decreased by desflurane, while IL-10 was increased.

The histopathological changes and levels of NF-κB protein in lung tissue were decreased by desflurane.

The results indicated that desflurane ameliorated VILI in a rat model of acute respiratory distress syndrome.