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Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine
Joint Authors
Maugeri, Andrea
Mazzone, Maria Grazia
Giuliano, Francesco
Barchitta, Martina
Agodi, Antonella
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Age-related macular degeneration (AMD) is the most common cause of visual loss in developed countries, with a significant economic and social burden on public health.
Although genome-wide and gene-candidate studies have been enabled to identify genetic variants in the complement system associated with AMD pathogenesis, the effect of gene-environment interaction is still under debate.
In this review we provide an overview of the role of complement system and its genetic variants in AMD, summarizing the consequences of the interaction between genetic and environmental risk factors on AMD onset, progression, and therapeutic response.
Finally, we discuss the perspectives of current evidence in the field of genomics driven personalized medicine and public health.
American Psychological Association (APA)
Maugeri, Andrea& Barchitta, Martina& Mazzone, Maria Grazia& Giuliano, Francesco& Agodi, Antonella. 2018. Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128588
Modern Language Association (MLA)
Maugeri, Andrea…[et al.]. Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1128588
American Medical Association (AMA)
Maugeri, Andrea& Barchitta, Martina& Mazzone, Maria Grazia& Giuliano, Francesco& Agodi, Antonella. Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128588