Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study
Joint Authors
Bjørneklett, Rune
Bostad, Leif
Fismen, Anne-Siri
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The value of a histologic classification scheme to classify patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into focal, mixed, crescentic, and sclerotic types for predicting risk of end-stage renal disease (ESRD) is well documented.
However, the prognostic value of histological classification specifically in elderly patients (≥70 years) with ANCA-GN has not previously been investigated.
Methods.
Patients with biopsy-verified pauci-immune necrotizing glomerulonephritis were identified from the Norwegian Kidney Biopsy Registry between 1991 and 2012 and those ≥70 years of age at the time of diagnosis and having positive anti-neutrophil cytoplasmic antibody serology were included in this study.
The incidence rate of ESRD and/or death was determined by linking the study cohort to the Norwegian Renal Registry and the Population Registry of Norway.
The ESRD-free survival and patient survival were compared between the 4 histological types.
Results.
Of the 81 patients included, 20 progressed to ESRD and 34 died.
The 1-year and 5-year ESRD-free survival varied between histological groups (p = 0.003) as follows: focal, 97% and 97%, respectively; mixed, 70% and 57%; crescentic, 76% and 63%; and sclerotic, 49% and 49%.
Patient survival did not differ significantly between groups (p = 0.30).
Conclusion.
Histological classification in elderly patients with ANCA-GN is useful for predicting ESRD but not survival.
American Psychological Association (APA)
Bjørneklett, Rune& Bostad, Leif& Fismen, Anne-Siri. 2018. Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128616
Modern Language Association (MLA)
Bjørneklett, Rune…[et al.]. Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128616
American Medical Association (AMA)
Bjørneklett, Rune& Bostad, Leif& Fismen, Anne-Siri. Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128616