Late Brain Involvement after Neonatal Immune Activation
Joint Authors
Dias, Paula
Freiberger, Viviane
Ventura, Letícia
Bragagnolo, Daiane
Dutra, Matheus L.
Horewicz, Verônica V.
Comim, Clarissa M.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The neonatal immune system is still immature, which makes it more susceptible to the infectious agents.
Neonatal immune activation is associated with increased permeability of the blood-brain barrier, causing an inflammatory cascade in the CNS and altering behavioral and neurochemical parameters.
One of the hypotheses that has been studied is that neuroinflammation may be involved in neurodegenerative processes, such as Alzheimer's disease (AD).
We evaluate visuospatial memory, cytokines levels, and the expression of tau and GSK-3β proteins in hippocampus and cortex of animals exposed to neonatal endotoxemia.
C57BL/6 mice aging two days received a single injection of subcutaneous lipopolysaccharide (LPS).
At 60,120, and 180 days of age, visual-spatial memory was evaluated and the hippocampus and cortex were dissected to evaluate the cytokines levels and expression of tau and GSK-3β proteins.
The animals exposed to LPS in the neonatal period present with visuospatial memory impairment at 120 and 180 days of age.
Here there was an increase of TNF-α and IL-1β levels in the hippocampus and cortex only at 60 days of age.
Here there was an increase in the expression of GSK-3β in hippocampus of the animals at 60, 120, and 180 days of age.
In the cortex, this increase occurred in the 120 and 180 days of age.
Tau protein expression was high in hippocampus and cortex at 120 days of age and in hippocampus at 180 days of age.
The data observed show that neonatal immune activation may be associated with visuospatial memory impairment, neuroinflammation, and increased expression of GSK-3β and Tau proteins in the long term.
American Psychological Association (APA)
Dias, Paula& Freiberger, Viviane& Ventura, Letícia& Bragagnolo, Daiane& Dutra, Matheus L.& Horewicz, Verônica V.…[et al.]. 2019. Late Brain Involvement after Neonatal Immune Activation. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128636
Modern Language Association (MLA)
Dias, Paula…[et al.]. Late Brain Involvement after Neonatal Immune Activation. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1128636
American Medical Association (AMA)
Dias, Paula& Freiberger, Viviane& Ventura, Letícia& Bragagnolo, Daiane& Dutra, Matheus L.& Horewicz, Verônica V.…[et al.]. Late Brain Involvement after Neonatal Immune Activation. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128636