Association between Gamma-Glutamyl Transferase and Coronary Atherosclerotic Plaque Vulnerability: An Optical Coherence Tomography Study
Joint Authors
Yang, Yi-Ning
Li, Xiao-Mei
Wang, Jun
Li, Xing
Pu, Jun
Jin, Siyu
Jia, Lu
Liu, Fen
Shan, Chunfang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Gamma-glutamyl transferase (GGT) has been detected in coronary plaques.
However, the association between serum GGT levels and coronary atherosclerotic plaque vulnerability in patients with coronary artery disease (CAD) as detected by optical coherence tomography (OCT) has not been investigated.
Methods.
We performed a retrospective study of consecutively enrolled CAD patients undergoing preintervention OCT examination during coronary angiography.
Plaque vulnerability was defined as the presence of ruptured plaques or thin-cap fibroatheroma (TCFA) upon OCT.
The association between serum GGT levels and coronary plaque vulnerability was evaluated using multivariate logistic regression analysis.
Results.
A total of 142 patients were included in our analysis.
OCT examination detected ruptured plaques in 16 patients, nonruptured plaques with TCFA in 17 patients, and nonruptured plaques and non-TCFA in 109 patients.
Univariate analyses showed that gender, diabetes, Apolipoprotein A1 (ApoA1) and high-density lipoprotein cholesterol (HDL-c), and diagnosis of acute coronary syndrome (ACS) were associated with plaque vulnerability (P all < 0.05).
Patients grouped according to serum GGT tertiles did not differ statistically in baseline characteristics or OCT findings.
Results of multivariate logistic analyses showed that diabetes and diagnosis of ACS were associated with plaque rupture and TCFA (P < 0.05).
Conclusions.
GGT serum levels were not associated with OCT detected coronary vulnerability in our cohort of CAD patient.
American Psychological Association (APA)
Wang, Jun& Li, Xing& Pu, Jun& Jin, Siyu& Jia, Lu& Li, Xiao-Mei…[et al.]. 2019. Association between Gamma-Glutamyl Transferase and Coronary Atherosclerotic Plaque Vulnerability: An Optical Coherence Tomography Study. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128658
Modern Language Association (MLA)
Wang, Jun…[et al.]. Association between Gamma-Glutamyl Transferase and Coronary Atherosclerotic Plaque Vulnerability: An Optical Coherence Tomography Study. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1128658
American Medical Association (AMA)
Wang, Jun& Li, Xing& Pu, Jun& Jin, Siyu& Jia, Lu& Li, Xiao-Mei…[et al.]. Association between Gamma-Glutamyl Transferase and Coronary Atherosclerotic Plaque Vulnerability: An Optical Coherence Tomography Study. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128658