RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy
Joint Authors
Szczepanski, Miroslaw J.
Migacz, Ewa
Olejarz, Wioletta
Nowicka, Grażyna
Łacheta, Dominika
Głuszko, Alicja
Kukwa, Wojciech
Tomaszewski, Piotr
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Receptor for advanced glycation end-products (RAGE) and toll-like receptors (TLRs) are the key factors indicating a danger to the organism.
They recognize the microbial origin pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs).
The primary response induced by PAMPs or DAMPs is inflammation.
Excessive stimulation of the innate immune system occurs in arterial wall with the participation of effector cells.
Persistent adaptive responses can also cause tissue damage and disease.
However, inflammation mediated by the molecules innate responses is an important way in which the adaptive immune system protects us from infection.
The specific detection of PAMPs and DAMPs by host receptors drives a cascade of signaling that converges at nuclear factor-κB (NF-κB) and interferon regulatory factors (IRFs) and induces the secretion of proinflammatory cytokines, type I interferon (IFN), and chemokines, which promote direct killing of the pathogen.
Therefore, signaling of these receptors’ pathways also appear to present new avenue for the modulation of inflammatory responses and to serve as potential novel therapeutic targets for antiatherosclerotic therapy.
American Psychological Association (APA)
Olejarz, Wioletta& Łacheta, Dominika& Głuszko, Alicja& Migacz, Ewa& Kukwa, Wojciech& Szczepanski, Miroslaw J.…[et al.]. 2018. RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128677
Modern Language Association (MLA)
Olejarz, Wioletta…[et al.]. RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1128677
American Medical Association (AMA)
Olejarz, Wioletta& Łacheta, Dominika& Głuszko, Alicja& Migacz, Ewa& Kukwa, Wojciech& Szczepanski, Miroslaw J.…[et al.]. RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128677