RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy

Joint Authors

Szczepanski, Miroslaw J.
Migacz, Ewa
Olejarz, Wioletta
Nowicka, Grażyna
Łacheta, Dominika
Głuszko, Alicja
Kukwa, Wojciech
Tomaszewski, Piotr

Source

BioMed Research International

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-08-26

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Receptor for advanced glycation end-products (RAGE) and toll-like receptors (TLRs) are the key factors indicating a danger to the organism.

They recognize the microbial origin pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs).

The primary response induced by PAMPs or DAMPs is inflammation.

Excessive stimulation of the innate immune system occurs in arterial wall with the participation of effector cells.

Persistent adaptive responses can also cause tissue damage and disease.

However, inflammation mediated by the molecules innate responses is an important way in which the adaptive immune system protects us from infection.

The specific detection of PAMPs and DAMPs by host receptors drives a cascade of signaling that converges at nuclear factor-κB (NF-κB) and interferon regulatory factors (IRFs) and induces the secretion of proinflammatory cytokines, type I interferon (IFN), and chemokines, which promote direct killing of the pathogen.

Therefore, signaling of these receptors’ pathways also appear to present new avenue for the modulation of inflammatory responses and to serve as potential novel therapeutic targets for antiatherosclerotic therapy.

American Psychological Association (APA)

Olejarz, Wioletta& Łacheta, Dominika& Głuszko, Alicja& Migacz, Ewa& Kukwa, Wojciech& Szczepanski, Miroslaw J.…[et al.]. 2018. RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128677

Modern Language Association (MLA)

Olejarz, Wioletta…[et al.]. RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1128677

American Medical Association (AMA)

Olejarz, Wioletta& Łacheta, Dominika& Głuszko, Alicja& Migacz, Ewa& Kukwa, Wojciech& Szczepanski, Miroslaw J.…[et al.]. RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128677

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1128677