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Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?
Joint Authors
Popescu, Ionela Daniela
Enciu, Ana-Maria
Hinescu, Mihail Eugen
Radu, Eugen
Ceafalan, Laura Cristina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Metastasis requires cellular changes related to cell-to-cell and cell-to-matrix adhesion, immune surveillance, activation of growth and survival signalling pathways, and epigenetic modifications.
In addition to tumour cells, tumour stroma is also modified in relationship to the primary tumour as well as to distant metastatic sites (forming a metastatic niche).
A common denominator of most stromal partners in tumour progression is CD36, a scavenger receptor for fatty acid uptake that modulates cell-to-extracellular matrix attachment, stromal cell fate (for adipocytes, endothelial cells), TGFβ activation, and immune signalling.
CD36 has been repeatedly proposed as a prognostic marker in various cancers, mostly of epithelial origin (breast, prostate, ovary, and colon) and also for hepatic carcinoma and gliomas.
Data gathered in preclinical models of various cancers have shown that blocking CD36 might prove beneficial in stopping metastasis spread.
However, targeting the receptor in clinical trials with thrombospondin mimetic peptides has proven ineffective, and monoclonal antibodies are not yet available for patient use.
This review presents data to support CD36 as a potential prognostic biomarker in cancer, its current stage towards achieving bona fide biomarker status, and knowledge gaps that must be filled before further advancement towards clinical practice.
American Psychological Association (APA)
Enciu, Ana-Maria& Radu, Eugen& Popescu, Ionela Daniela& Hinescu, Mihail Eugen& Ceafalan, Laura Cristina. 2018. Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128692
Modern Language Association (MLA)
Enciu, Ana-Maria…[et al.]. Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1128692
American Medical Association (AMA)
Enciu, Ana-Maria& Radu, Eugen& Popescu, Ionela Daniela& Hinescu, Mihail Eugen& Ceafalan, Laura Cristina. Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128692