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GSK-3 Inhibitor Promotes Neuronal Cell Regeneration and Functional Recovery in a Rat Model of Spinal Cord Injury
Joint Authors
Tian, Xinggui
Lei, Fei
He, Wen
Zhou, Qingzhong
Zheng, Lipeng
Kang, Jianping
Song, Yueming
Feng, Daxiong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The reparative process following spinal cord injury (SCI) is extremely complicated.
Cells in the microenvironment express multiple inhibitory factors that affect axonal regeneration over a prolonged period of time.
The axon growth inhibitory factor glycogen synthase kinase-3 (GSK-3) is an important factor during these processes.
TDZD-8 (4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione) is the most effective and specific non-ATP-competitive inhibitor of GSK-3.
Here, we show that administering TDZD-8 after SCI was associated with significantly inhibited neuronal apoptosis, upregulated GAP-43 expression, increased density of cortical spinal tract fibers around areas of injury, and increased Basso, Beattie, and Bresnahan (BBB) scores in the lower limbs.
These findings support the notion that GSK-3 inhibitors promote neuronal cell regeneration and lower limb functional recovery.
American Psychological Association (APA)
Lei, Fei& He, Wen& Tian, Xinggui& Zhou, Qingzhong& Zheng, Lipeng& Kang, Jianping…[et al.]. 2019. GSK-3 Inhibitor Promotes Neuronal Cell Regeneration and Functional Recovery in a Rat Model of Spinal Cord Injury. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128704
Modern Language Association (MLA)
Lei, Fei…[et al.]. GSK-3 Inhibitor Promotes Neuronal Cell Regeneration and Functional Recovery in a Rat Model of Spinal Cord Injury. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1128704
American Medical Association (AMA)
Lei, Fei& He, Wen& Tian, Xinggui& Zhou, Qingzhong& Zheng, Lipeng& Kang, Jianping…[et al.]. GSK-3 Inhibitor Promotes Neuronal Cell Regeneration and Functional Recovery in a Rat Model of Spinal Cord Injury. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128704