Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota
Joint Authors
Zhou, Guo-Feng
Jiang, Yue-Hua
Ma, Du-Fang
Wang, Yong-Cheng
Yang, Jin-Long
Chen, Ji-Ye
Chi, Chen-Yu
Han, Xiao-wei
Li, Zhao-Yu
Li, Xiao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-18
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
Changes in the gut microbiota are associated with cardiovascular disease progression.
Xiao-Qing-Long Tang (XQLT), a traditional herbal formula, has an anti-inflammatory effect and regulates the steady state of the immune system, which is also associated with the progression of heart failure with preserved ejection faction (HFpEF).
In this study, we investigated whether XQLT could contribute to prevent the development of HFpEF and whether the modulation of the gut microbiota by this herbal formula could be involved in such effect.
Methods.
The gut microbiota, SCFAs, the histology/function of the heart, and systolic blood pressure were examined to evaluate the effect of XQLT on the gut microbiota and the progression of HFpEF after oral administration of XQLT to model rats.
Furthermore, we evaluated, through fecal microbiota transplantation experiments, whether the favorable effects of XQLT could be mediated by the gut microbiota.
Results.
Oral administration of XQLT contributed to the reduction of elevated blood pressure, inflammation, and compensatory hypertrophy, features that are associated with the progression of HFpEF.
The gut microbiota composition, SCFA levels, and intestinal mucosal histology were improved after treatment with XQLT.
Moreover, fecal transfer from XQLT-treated rats was sufficient to prevent the progression of HFpEF.
Conclusions.
These data suggested that XQLT prevented the development of HFpEF in model rats by regulating the composition of the gut microbiota.
American Psychological Association (APA)
Zhou, Guo-Feng& Jiang, Yue-Hua& Ma, Du-Fang& Wang, Yong-Cheng& Yang, Jin-Long& Chen, Ji-Ye…[et al.]. 2019. Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota. BioMed Research International،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1128712
Modern Language Association (MLA)
Zhou, Guo-Feng…[et al.]. Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota. BioMed Research International No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1128712
American Medical Association (AMA)
Zhou, Guo-Feng& Jiang, Yue-Hua& Ma, Du-Fang& Wang, Yong-Cheng& Yang, Jin-Long& Chen, Ji-Ye…[et al.]. Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1128712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128712