The Diagnostic Value of Quantitative CT Analysis of Ground-Glass Volume Percentage in Differentiating Epidermal Growth Factor Receptor Mutation and Subtypes in Lung Adenocarcinoma
Joint Authors
Wang, Hexiang
Lin, Jizheng
Guo, Hongwei
Wang, Zeguo
Shan, Bao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To retrospectively investigate computed tomographic (CT) quantitative analysis of ground-glass opacity (GGO) volume percentage and morphologic features of resected lung adenocarcinomas according to epidermal growth factor receptor (EGFR) mutation status and subtypes.
Methods.
Amplification refractory mutation system was used to detect mutations in the EGFR gene.
Distribution of demographics and GGO volume percentage were performed according to EGFR mutation status and subtypes.
Results.
EGFR mutations were significantly more frequent in women (55.2% vs.
37.0%, p=0.001) and in never-smokers (59.5% vs.
38.4%, p < 0.001) than those without EGFR mutation.
GGO volume percentage was significantly higher in tumors with EGFR mutation than in tumors without EGFR mutation (52.8±25.7% vs.
29.0±20.7%, p < 0.001).
The GGO volume percentages in tumors with exon 21 mutation and EGFR mutation showed a significant difference compared with those without EGFR mutation (p < 0.001, area under the curve=0.871, sensitivity=94.6%, specificity=73.8%, and p < 0.001, area under the curve=0.783, sensitivity=69.9%, specificity=75.4%, resp.), with cut-off values of 37.7% and 34.3% in receiver operating characteristic curve analysis.
Conclusion.
GGO volume percentage in adenocarcinomas with EGFR mutation was significantly higher than that in tumors without EGFR mutation, and adenocarcinomas with exon 21 mutation showed significantly higher GGO volume percentage than in tumors with exon 19 mutation and those without EGFR mutation.
Our results indicate that GGO volume percentage cut-off values of more than 37.7% and 34.3% were predictors of positive exon 21 mutation and EGFR mutation, respectively.
American Psychological Association (APA)
Wang, Hexiang& Guo, Hongwei& Wang, Zeguo& Shan, Bao& Lin, Jizheng. 2019. The Diagnostic Value of Quantitative CT Analysis of Ground-Glass Volume Percentage in Differentiating Epidermal Growth Factor Receptor Mutation and Subtypes in Lung Adenocarcinoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128725
Modern Language Association (MLA)
Wang, Hexiang…[et al.]. The Diagnostic Value of Quantitative CT Analysis of Ground-Glass Volume Percentage in Differentiating Epidermal Growth Factor Receptor Mutation and Subtypes in Lung Adenocarcinoma. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1128725
American Medical Association (AMA)
Wang, Hexiang& Guo, Hongwei& Wang, Zeguo& Shan, Bao& Lin, Jizheng. The Diagnostic Value of Quantitative CT Analysis of Ground-Glass Volume Percentage in Differentiating Epidermal Growth Factor Receptor Mutation and Subtypes in Lung Adenocarcinoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128725