A Review of the Genetics and Pathogenesis of Syndactyly in Humans and Experimental Animals: A 3-Step Pathway of Pathogenesis
Author
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Embryology of normal web space creation and the genetics of syndactyly in humans and experimental animals are well described in the literature.
In this review, the author offers a 3-step pathway of pathogenesis for syndactyly.
The first step is initiated either by the overactivation of the WNT canonical pathway or the suppression of the Bone Morphogenetic Protein (BMP) canonical pathway.
This leads to an overexpression of Fibroblast Growth Factor 8 (FGF8).
The final step is the suppression of retinoic acid in the interdigital mesenchyme leading to suppression of both apoptosis and extracellular matrix (ECM) degradation, resulting in syndactyly.
American Psychological Association (APA)
al-Qattan, Mohammad M.. 2019. A Review of the Genetics and Pathogenesis of Syndactyly in Humans and Experimental Animals: A 3-Step Pathway of Pathogenesis. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128732
Modern Language Association (MLA)
al-Qattan, Mohammad M.. A Review of the Genetics and Pathogenesis of Syndactyly in Humans and Experimental Animals: A 3-Step Pathway of Pathogenesis. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1128732
American Medical Association (AMA)
al-Qattan, Mohammad M.. A Review of the Genetics and Pathogenesis of Syndactyly in Humans and Experimental Animals: A 3-Step Pathway of Pathogenesis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128732
