Interactions between the Cyclooxygenase Metabolic Pathway and the Renin-Angiotensin-Aldosterone Systems: Their Effect on Cardiovascular Risk, from Theory to the Clinical Practice
Joint Authors
Szahidewicz-Krupska, E.
Doroszko, A.
Gawrys, Jakub
Gawrys, Karolina
Derkacz, Arkadiusz
Mochol, Jakub
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Coronary artery disease (CAD) and stroke are the most common and serious long-term complications of hypertension.
Acetylsalicylic acid (ASA) significantly reduces their incidence and cardiovascular mortality.
The RAAS activation plays an important role in pathogenesis of CVD, resulting in increased vascular resistance, proliferation of vascular-smooth-muscle-cells, and cardiac hypertrophy.
Drugs acting on the renin-angiotensin-aldosterone system (RAAS) are demonstrated to reduce cardiovascular events in population with cardiovascular disease (CVD).
The cyclooxygenase inhibitors limit the beneficial effect of RAAS-inhibitors, which in turn may be important in subjects with hypertension, CAD, and congestive heart failure.
These observations apply to most of nonsteroidal anti-inflammatory drugs and ASA at high doses.
Nevertheless, there is no strong evidence confirming presence of similar effects of cardioprotective ASA doses.
The benefit of combined therapy with low-doses of ASA is—in some cases—significantly higher than that of monotherapy.
So far, the significance of ASA in optimizing the pharmacotherapy remains not fully established.
A better understanding of its influence on the particular CVD should contribute to more precise identification of patients in whom benefits of ASA outweigh the complication risk.
This brief review summarizes the data regarding usefulness and safety of the ASA combination with drugs acting directly on the RAAS.
American Psychological Association (APA)
Gawrys, Jakub& Gawrys, Karolina& Szahidewicz-Krupska, E.& Derkacz, Arkadiusz& Mochol, Jakub& Doroszko, A.. 2018. Interactions between the Cyclooxygenase Metabolic Pathway and the Renin-Angiotensin-Aldosterone Systems: Their Effect on Cardiovascular Risk, from Theory to the Clinical Practice. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128763
Modern Language Association (MLA)
Gawrys, Jakub…[et al.]. Interactions between the Cyclooxygenase Metabolic Pathway and the Renin-Angiotensin-Aldosterone Systems: Their Effect on Cardiovascular Risk, from Theory to the Clinical Practice. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1128763
American Medical Association (AMA)
Gawrys, Jakub& Gawrys, Karolina& Szahidewicz-Krupska, E.& Derkacz, Arkadiusz& Mochol, Jakub& Doroszko, A.. Interactions between the Cyclooxygenase Metabolic Pathway and the Renin-Angiotensin-Aldosterone Systems: Their Effect on Cardiovascular Risk, from Theory to the Clinical Practice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128763