The Possible Pathogenesis of Idiopathic Pulmonary Fibrosis considering MUC5B
Joint Authors
Zhang, Qinghua
Wang, Yan
Qu, Danhua
Yu, Jinyan
Yang, Junling
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Overexpression of the MUC5B protein is associated with idiopathic pulmonary fibrosis (IPF), but little information is available regarding the pathogenic effects and regulatory mechanisms of overexpressed MUC5B in IPF.
Main Body.
The overexpression of MUC5B in terminal bronchi and honeycomb cysts produces mucosal host defensive dysfunction in the distal airway which may play an important role in the development of IPF.
This review addresses the possible association of overexpression of MUC5B, with MUC5B promoter polymorphism, MUC5B gene epigenetic changes, effects of some transcriptional factors, and inflammatory mediators in IPF.
In addition, the associated signaling pathways which may influence the expression of MUC5B are also discussed.
Conclusion.
This work has important implications for further exploration of the mechanisms of overexpression of MUC5B in IPF, and future personalized treatment.
American Psychological Association (APA)
Zhang, Qinghua& Wang, Yan& Qu, Danhua& Yu, Jinyan& Yang, Junling. 2019. The Possible Pathogenesis of Idiopathic Pulmonary Fibrosis considering MUC5B. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128764
Modern Language Association (MLA)
Zhang, Qinghua…[et al.]. The Possible Pathogenesis of Idiopathic Pulmonary Fibrosis considering MUC5B. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1128764
American Medical Association (AMA)
Zhang, Qinghua& Wang, Yan& Qu, Danhua& Yu, Jinyan& Yang, Junling. The Possible Pathogenesis of Idiopathic Pulmonary Fibrosis considering MUC5B. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128764