Advances in Gut Microbiota of Viral Hepatitis Cirrhosis
Joint Authors
Wang, Yixuan
Pan, Calvin Q.
Xing, Huichun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although gut dysbiosis appears in 20%–75% of cirrhotic patients, there are limited data on microbiota profiles in viral hepatitis cirrhotics and its role in progression to cirrhosis.
Further understanding on the relationship between gut dysbiosis and cirrhosis presents a unique opportunity in not only predicting the development of cirrhosis but also discovering new therapies.
Recent advances have been made on identifying unique microbiota in viral hepatitis cirrhotics and adopting the microbiota index to predict cirrhosis.
Therapeutic intervention with microbiome-modulating has been explored.
Cirrhosis from viral infection has unique bacterial or fungal profiles, which include increased numbers of Prevotella, Streptococcus, Staphylococcaceae, and Enterococcus, as well as decreased Ruminococcus and Clostridium.
In addition, the gut microbiota can stimulate liver immunity, effectively helping hepatitis virus clearance.
In clinical settings, CDR, GDI, Basidiomycota/Ascomycota, specific POD, and so forth are efficient microbiota indexes to diagnose or prognosticate cirrhosis from viral hepatitis.
FMT, probiotics, and prebiotics can restore microbial diversity in cirrhotic patients with viral hepatitis, decrease ammonia serum or endotoxemia levels, prevent complications, reduce rehospitalization rate, and improve prognosis.
Cirrhotics from viral hepatitis had unique bacterial or fungal profiles, associated with specific metabolic, immune, and endocrinological statuses.
Such profiles are modifiable with medical treatment.
The role of gut archaea and virome, implementation of FMT, microbiota metabolites as adjuvant immunotherapy, and microbiota indexes for prognostication deserve attention.
American Psychological Association (APA)
Wang, Yixuan& Pan, Calvin Q.& Xing, Huichun. 2019. Advances in Gut Microbiota of Viral Hepatitis Cirrhosis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128774
Modern Language Association (MLA)
Wang, Yixuan…[et al.]. Advances in Gut Microbiota of Viral Hepatitis Cirrhosis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1128774
American Medical Association (AMA)
Wang, Yixuan& Pan, Calvin Q.& Xing, Huichun. Advances in Gut Microbiota of Viral Hepatitis Cirrhosis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1128774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128774