Multiorgan Drug Action of Levosimendan in Critical Illnesses
Joint Authors
Pan, Jian
Yang, Yun-Mei
Zhu, Jian-Yong
Lu, Yuan-Qiang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardiotonic drugs mainly include digitalis, catecholamines, phosphodiesterase inhibitors, and calcium sensitizers, which have been successively discovered and applied in clinical practice.
However, there are only a few new drugs available in this field, and the selection is very limited.
Digitalis, catecholamines, and phosphodiesterase inhibitors increase myocardial contractility by increasing intracellular concentrations of cyclic adenosine monophosphate (cAMP) and Ca2+, and this increase in intracellular calcium ion concentration enhances myocardial oxygen consumption and causes arrhythmia.
For these reasons, the research focus on positive inotropic agents has shifted from calcium mobilization to calcium sensitization.
Intracellular calcium sensitizers are more effective and safer drugs because they do not increase the intracellular concentration of calcium ions.
However, only three calcium sensitizers have been fully developed and used in the past three decades.
One of these drugs, levosimendan, has multiple molecular targets and exerts its pharmacological effects by not only increasing myocardial contractility, but also enhancing respiratory muscle function and liver and kidney protection, and it is useful for patients with severe sepsis and septic shock.
Recently, more than 60 randomized controlled clinical trials of levosimendan have been reported; however, these clinical trials have occasionally shown different findings.
This article reviews the research progress of levosimendan in critical illnesses in recent years.
American Psychological Association (APA)
Pan, Jian& Yang, Yun-Mei& Zhu, Jian-Yong& Lu, Yuan-Qiang. 2019. Multiorgan Drug Action of Levosimendan in Critical Illnesses. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128779
Modern Language Association (MLA)
Pan, Jian…[et al.]. Multiorgan Drug Action of Levosimendan in Critical Illnesses. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1128779
American Medical Association (AMA)
Pan, Jian& Yang, Yun-Mei& Zhu, Jian-Yong& Lu, Yuan-Qiang. Multiorgan Drug Action of Levosimendan in Critical Illnesses. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128779