Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis
Joint Authors
Ding, Jianing
Wang, Xin
Chen, Bi
Zhang, Jieyuan
Xu, Jianguang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis.
This study, aimed to investigate whether exosomes originated from bone marrow-derived MSCs (BMSCs) preconditioned by deferoxamine (DFO-Exos) exhibited superior proangiogenic property in wound repair and to explore the underlying mechanisms involved.
Human umbilical vein endothelial cells (HUVECs) were used for assays involving cell proliferation, scratch wound healing, and tube formation.
To test the effects in vivo, streptozotocin-induced diabetic rats were established.
Two weeks after the procedure, histological analysis was used to measure wound-healing effects, and the neovascularization was evaluated as well.
Our findings demonstrated that DFO-Exos activate the PI3K/AKT signaling pathway via miR-126 mediated PTEN downregulation to stimulate angiogenesis in vitro.
This contributed to enhanced wound healing and angiogenesis in streptozotocin-induced diabetic rats in vivo.
Our results suggest that, in cell-free therapies, exosomes derived from DFO preconditioned stem cells manifest increased proangiogenic ability.
American Psychological Association (APA)
Ding, Jianing& Wang, Xin& Chen, Bi& Zhang, Jieyuan& Xu, Jianguang. 2019. Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128797
Modern Language Association (MLA)
Ding, Jianing…[et al.]. Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1128797
American Medical Association (AMA)
Ding, Jianing& Wang, Xin& Chen, Bi& Zhang, Jieyuan& Xu, Jianguang. Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128797