Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody
Joint Authors
Masui, Kenta
Komori, Takashi
Kato, Yukinari
Masutomi, Kenkichi
Ichimura, Koichi
Ogasawara, Satoshi
Kaneko, Mika K.
Oki, Hiroharu
Suzuki, Hiroyoshi
Nitta, Masayuki
Maruyama, Takashi
Muragaki, Yoshihiro
Kawamata, Takakazu
Sawada, Tatsuo
Shibata, Noriyuki
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Telomerase reverse transcriptase (TERT) is important for the biology of diffuse gliomas.
TERT promoter mutations are selectively observed among 1p/19q-codeleted oligodendrogliomas and isocitrate dehydrogenase gene- (IDH-) wildtype glioblastoma (GBM).
However, TERT transcripts range widely in various cancers including gliomas, and TERT protein expression has been rarely investigated thus far.
It would be thus critical to examine the expression level of TERT in tumors in addition to its mutational status, and sensitive and specific methods are urgently needed to examine TERT protein expression for the assessment of TERT biology in gliomas.
Using our newly developed TERT-specific monoclonal antibody (TMab-6) applicable to human tissue, we found an unexpected increase in TERT expression in TERT-wildtype as well as TERT-mutated gliomas and in tumor vasculature.
This is the first extensive analysis on the expression of TERT immunoreactivity in human glioma tissue, suggesting that TERT protein expression may be regulated by several mechanisms in addition to its promoter mutation.
American Psychological Association (APA)
Masui, Kenta& Komori, Takashi& Kato, Yukinari& Masutomi, Kenkichi& Ichimura, Koichi& Ogasawara, Satoshi…[et al.]. 2018. Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128804
Modern Language Association (MLA)
Masui, Kenta…[et al.]. Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1128804
American Medical Association (AMA)
Masui, Kenta& Komori, Takashi& Kato, Yukinari& Masutomi, Kenkichi& Ichimura, Koichi& Ogasawara, Satoshi…[et al.]. Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128804