PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population
Joint Authors
Cui, Daxiang
Wang, Wei
Lei, Xiaoying
Yan, Zhen
Liang, Ping
Zhang, Wentao
Wang, Weihua
Dai, Peng
Wang, Qin
Yan, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The reported risk susceptibility between phospholipase C epsilon 1 (PLCE1) polymorphisms and esophageal cancer (EC) and gastric cancer (GC) remained inconsistent and controversial, especially on variants other than rs2274223.
The relationship between PLCE1 polymorphisms and gene expression is also unclear.
Here we conducted a case-control study from northwest China, genotyped seven tag single nucleotide polymorphisms (SNPs) in PLCE1 with multiplexed SNP MassARRAY assay.
Stratified analysis was carried out and PLCE1 expression was evaluated in specified groups with the method of qRT-PCR and immunohistochemistry.
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
Linkage disequilibrium analysis revealed protective haplotypes of CCAAGTC and CCAA.
By stratification, a more significant association was found in subgroups of male, age ≥ 54, tumor stages of I-II and tumor size ≤ 5 cm, EC and cardia cancer (CC) of stomach, and moderate to well differentiated squamous carcinoma.
In addition, a significant association for rs3765524 with noncardia cancer (NCC) and adenocarcinoma which is predominant in China was also observed.
Further expression analysis identified that PLCE1 was downregulated in NCC tissues comparing to their adjacent noncancerous tissues, and its protein expression was higher in genotype rs3765524 CT/TT than in rs3765524 CC.
In summary, our study suggests that PLCE1 polymorphisms may affect its gene expression and are associated with not only EC and CC, but also, to some extent, NCC risk in this study population.
American Psychological Association (APA)
Liang, Ping& Zhang, Wentao& Wang, Weihua& Dai, Peng& Wang, Qin& Yan, Wei…[et al.]. 2019. PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128821
Modern Language Association (MLA)
Liang, Ping…[et al.]. PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1128821
American Medical Association (AMA)
Liang, Ping& Zhang, Wentao& Wang, Weihua& Dai, Peng& Wang, Qin& Yan, Wei…[et al.]. PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1128821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128821