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Application of Calcium Sulfate for Dead Space Management in Soft Tissue: Characterisation of a Novel In Vivo Response
Joint Authors
Walsh, W. R.
Oliver, Rema A.
Lovric, Vedran
Christou, Chris
Aiken, Sean S.
Cooper, John J.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Management of dead space (DS) is a fundamental aspect of surgery.
Residual DS following surgery can fill with hematoma and provide an environment for bacterial growth, increasing the incidence of postoperative infection.
Materials for managing DS include polymethyl-methacrylate (PMMA), which is nonresorbing and requires removal in a second surgical procedure.
The use of calcium sulfate (CS) offers the advantage of being fully absorbed and does not require subsequent surgical removal.
As CS has historically been used as a bone void filler, there are some concerns for the risk of heterotopic ossification (HO) when implanted adjacent to soft tissue.
This study assessed the osteoinductive potential of CS and identified and characterised residual material present in muscle tissue using histology, energy-dispersive X-ray spectroscopy analysis, and scanning electron microscopy (SEM).
CS beads with and without antibiotic were implanted in intramuscular sites in both athymic rats and New Zealand white rabbits.
At 28 days after implantation in the rat model, no signs of osteoinduction were observed.
In the rabbit model, at 21 days after implantation, almost complete bead absorption and presence of a “halo” of material in the surrounding muscle tissue were confirmed.
Our results suggested that the halo of material was a calcium phosphate precipitate, not HO.
American Psychological Association (APA)
Oliver, Rema A.& Lovric, Vedran& Christou, Chris& Aiken, Sean S.& Cooper, John J.& Walsh, W. R.. 2018. Application of Calcium Sulfate for Dead Space Management in Soft Tissue: Characterisation of a Novel In Vivo Response. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128872
Modern Language Association (MLA)
Oliver, Rema A.…[et al.]. Application of Calcium Sulfate for Dead Space Management in Soft Tissue: Characterisation of a Novel In Vivo Response. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128872
American Medical Association (AMA)
Oliver, Rema A.& Lovric, Vedran& Christou, Chris& Aiken, Sean S.& Cooper, John J.& Walsh, W. R.. Application of Calcium Sulfate for Dead Space Management in Soft Tissue: Characterisation of a Novel In Vivo Response. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128872