Evaluation of Red Cell Distribution Width to Lymphocyte Ratio as Potential Biomarker for Detection of Colorectal Cancer
Joint Authors
Liu, Shun
Huang, Jiahao
Zhao, Yang
Liao, Lin
Lu, Shaolong
Wu, Changtao
Wei, Chuanyi
Xu, Shaoqiang
Zhong, Huage
Liu, Junjie
Guo, Yun
Zhang, Sen
Gao, Feng
Tang, Weizhong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aim.
Colorectal cancer (CRC) is the third most lethal cancer globally.
This study sought to determine the feasibility of using red cell distribution width-to-lymphocyte ratio (RLR) as a tool to facilitate CRC detection.
Methods.
Seventy-eight healthy controls, 162 patients diagnosed with CRC, and 94 patients with colorectal polyps (CP) from June 2017 to October 2018 were retrospectively reviewed.
Clinical data were obtained to analyze preoperative RLR level, and receiver operating characteristic (ROC) curve analysis was performed to estimate the potential role of RLR as a CRC biomarker.
Results.
RLR was higher in patients with CRC than in healthy participants (P < 0.05).
ROC analysis indicated that combined detection of RLR and CEA appears to be a more effective marker to distinguish among controls, CP, and CRC patients, yielding 56% sensitivity and 90% specificity.
RLR levels were significantly greater in those who had more advanced TNM stages (P < 0.05) and patients with distant metastasis stages (P < 0.05).
Conclusions.
RLR might serve as a potential biomarker for CRC diagnosis.
American Psychological Association (APA)
Huang, Jiahao& Zhao, Yang& Liao, Lin& Liu, Shun& Lu, Shaolong& Wu, Changtao…[et al.]. 2019. Evaluation of Red Cell Distribution Width to Lymphocyte Ratio as Potential Biomarker for Detection of Colorectal Cancer. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1128884
Modern Language Association (MLA)
Huang, Jiahao…[et al.]. Evaluation of Red Cell Distribution Width to Lymphocyte Ratio as Potential Biomarker for Detection of Colorectal Cancer. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1128884
American Medical Association (AMA)
Huang, Jiahao& Zhao, Yang& Liao, Lin& Liu, Shun& Lu, Shaolong& Wu, Changtao…[et al.]. Evaluation of Red Cell Distribution Width to Lymphocyte Ratio as Potential Biomarker for Detection of Colorectal Cancer. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1128884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128884