Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells
Joint Authors
Wang, Shangquan
Wei, Xu
Zhan, Jia-Wen
Feng, Minshan
Zhu, Liguo
Xunlu, Yin
Jie, Yu
He, Yin
Long, Liang
Tao, Han
Xuepeng, Li
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Low back pain is a major cause of disability worldwide.
Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown.
Published studies found the unbalance of anabolism and catabolism of annulus fibrosus (AF) played an important role in it.
The present study was aimed to identify the potential targets and signaling pathways of IDD, through the combined analysis of differential expression and based on the Gene Expression Omnibus (GEO) dataset from NCBI.
PPI Networks Analysis indicated that MMP2 and AGE-RAGE signaling pathway and estrogen signaling pathway may play important roles in initiation and development of IDD.
This study forecasted the pathogenesis molecular mechanism of IDD and the potential prognostic and diagnostic biomarkers, but we need to make further molecular biological experiments to confirm our assumptions.
American Psychological Association (APA)
Xunlu, Yin& Feng, Minshan& Zhu, Liguo& Zhan, Jia-Wen& Wei, Xu& Jie, Yu…[et al.]. 2019. Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128908
Modern Language Association (MLA)
Xunlu, Yin…[et al.]. Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1128908
American Medical Association (AMA)
Xunlu, Yin& Feng, Minshan& Zhu, Liguo& Zhan, Jia-Wen& Wei, Xu& Jie, Yu…[et al.]. Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1128908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128908