Potential of Gene and Cell Therapy for Inner Ear Hair Cells
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex.
The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices.
Various kinds of hearing devices are available but, despite recent advancements, their perceived sound quality does not mimic that of the “naïve” cochlea.
Damage to crucial cochlear structures is mostly irreversible and results in permanent hearing loss.
Cochlear HC regeneration has long been an important goal in the field of hearing research.
However, it remains challenging because, thus far, no medical treatment has successfully regenerated cochlear HCs.
Recent advances in genetic modulation and developmental techniques have led to novel approaches to generating HCs or protecting against HC loss, to preserve hearing.
In this review, we present and review the current status of two different approaches to restoring or protecting hearing, gene therapy, including the newly introduced CRISPR/Cas9 genome editing, and stem cell therapy, and suggest the future direction.
American Psychological Association (APA)
Lee, Min Young& Park, Yong-Ho. 2018. Potential of Gene and Cell Therapy for Inner Ear Hair Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128911
Modern Language Association (MLA)
Lee, Min Young& Park, Yong-Ho. Potential of Gene and Cell Therapy for Inner Ear Hair Cells. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1128911
American Medical Association (AMA)
Lee, Min Young& Park, Yong-Ho. Potential of Gene and Cell Therapy for Inner Ear Hair Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128911