Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus
Joint Authors
Zhu, Zheng
Wang, Chun
Xiang, Quanyong
Wang, Yijun
Chen, Gang
Tu, Qingyun
Wu, Junxia
Qin, Yu
Shen, Yi
Yan, Li
Han, Aohan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
AQP7 and AQP9 represent glycerol channel in adipose tissue and liver and have been associated with metabolic diseases.
We aimed to investigate the associations between genetic variants in AQP7 and AQP9 genes and the risk of type 2 diabetes (T2DM) in Chinese population.
Methods.
Blood samples were drawn from 400 T2DM patients and 400 age- and gender-matched controls.
Genomic DNA was extracted by proteinase K digestion and phenol–chloroform extraction.
Genotyping of 5 single nucleotide polymorphisms (SNPs) in AQP7 (rs2989924, rs3758269, and rs62542743) and AQP9 (rs57139208, rs16939881) was performed by the polymerase chain reaction assay with TaqMan probes.
Results.
The subjects with rs2989924 GA+AA genotypes had 1.47-fold increased risk of T2DM (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.06-2.04), compared to those with GG genotype, and this association remained significant after adjustment for covariates (OR 1.66, 95% CI 1.07-2.57).
When compared with rs3758269 CC genotype, the subjects with CT+TT genotypes had 45% decreased T2DM risk after multivariate adjustment (OR 0.55, 95% CI 0.35-0.85).
The associations were evident in elder and overweight subjects and those with central obesity.
No association was observed between AQP9 SNPs and T2DM risk.
Conclusions.
AQP7 SNP rs2989924 and rs3758269 were associated with T2DM risk in Chinese Han population.
American Psychological Association (APA)
Wang, Yijun& Chen, Gang& Tu, Qingyun& Wu, Junxia& Qin, Yu& Zhu, Zheng…[et al.]. 2018. Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128926
Modern Language Association (MLA)
Wang, Yijun…[et al.]. Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128926
American Medical Association (AMA)
Wang, Yijun& Chen, Gang& Tu, Qingyun& Wu, Junxia& Qin, Yu& Zhu, Zheng…[et al.]. Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128926