p300CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis
Joint Authors
Yao, Weilei
Wang, Tongxin
Huang, Feiruo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The overwhelming frequency of metabolic diseases such as obesity and diabetes are closely related to liver diseases, which might share common pathogenic signaling processes.
These metabolic disorders in the presence of inflammatory response seem to be triggered by and to reside in the liver, which is the central metabolic organ that plays primary roles in regulating lipid and glucose homeostasis upon alterations of metabolic conditions.
Recently, abundant emerging researches suggested that p300 and CREB binding protein (CBP) are crucial regulators of energy homeostasis and liver fibrosis through both their acetyltransferase activities and transcriptional coactivators.
Plenty of recent findings demonstrated the potential roles of p300/CBP in mammalian metabolic homeostasis in response to nutrients.
This review is focused on the different targets and functions of p300/CBP in physiological and pathological processes, including lipogenesis, lipid export, gluconeogenesis, and liver fibrosis, also provided some nutrients as the regulator of p300/CBP for nutritional therapeutic approaches to treat liver diseases.
American Psychological Association (APA)
Yao, Weilei& Wang, Tongxin& Huang, Feiruo. 2018. p300CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128934
Modern Language Association (MLA)
Yao, Weilei…[et al.]. p300CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1128934
American Medical Association (AMA)
Yao, Weilei& Wang, Tongxin& Huang, Feiruo. p300CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128934